Results 111 to 120 of about 37,116 (209)
Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes. [PDF]
, 2016 Glucocorticoids and FoxO3 exert similar metabolic effects in skeletal muscle. FoxO3 gene expression was increased by dexamethasone (Dex), a synthetic glucocorticoid, both in vitro and in vivo.
Chau, Andy +10 more
core +1 more source
Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription
Retrovirology, 2006 Background Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency virus (AIDS). Following entry into the host cell, the viral RNA is reverse transcribed into DNA and subsequently integrated into the host genome as
Pumfery Anne +4 more
doaj +1 more source
Mechanisms of enhancer‐driven oncogene activation
International Journal of Cancer, Volume 158, Issue 2, Page 333-341, 15 January 2026.Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend +2 more
wiley +1 more source
The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake [PDF]
, 2016 The anti-atherogenic cytokine TGF-β inhibits macrophage foam cell formation by suppressing the expression of key genes implicated in the uptake of modified lipoproteins.
Ashlin, Tim G. +6 more
core +2 more sources
The Journal of biological chemistry, 2001 Among the extracellular signals that modulate the synthesis of collagen, transforming growth factor-beta (TGF-beta) and interferon-gamma (IFN-gamma) are preeminent. These two cytokines exert antagonistic effects on fibroblasts, and play important roles in the physiologic regulation of extracellular matrix turnover.
A K, Ghosh +4 more
openaire +1 more source
ETS-targeted therapy: can it substitute for MEK inhibitors?
Clinical and Translational Medicine, 2017 Background The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues.
Osamu Tetsu, Frank McCormick
doaj +1 more source
Enhancer‐dependent gene regulation in space, time, and malignancies
International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum +2 more
wiley +1 more source
Structural insights into TAZ2 domain–mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A [PDF]
, 2020 Marina Lochhead +9 more
openalex +1 more source
, 2005 Innate and adaptive immunity are connected via antigen processing and presentation (APP), which results in the presentation of antigenic peptides to T cells in the complex with the major histocompatibility (MHC) determinants.
Drozina, G. +3 more
core +2 more sources
PLoS ONE, 2014 IntroductionEpigenetic modification plays a critical role in regulating gene expression. To understand how epigenetic modification alters miRNA expression in monocyte-derived dendritic cells (moDCs) in different environments, we analyzed the connections ...
Shiyue Mei +10 more
doaj +1 more source