Results 121 to 130 of about 37,116 (209)

A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao, Xudong Feng, Qigu Yao, Weiqin Ji, Xinying Zhang, Qiaoling Pan, Bin Zhu, Jiong Yu, Hongcui Cao, Xianfeng Zhang   +9 more
wiley   +1 more source

The Long Non‐Coding RNA Obesity‐Related (Obr) Contributes To Lipid Metabolism Through Epigenetic Regulation

Advanced Science
Obesity is a multifactorial disease that is part of today's epidemic and also increases the risk of other metabolic diseases. Long noncoding RNAs (lncRNAs) provide one tier of regulatory mechanisms to maintain metabolic homeostasis.
Suneesh Kaimala, Shareena Saeed Lootah, Neha Mehra, Challagandla Anil Kumar, Saeeda Al Marzooqi, Prabha Sampath, Suraiya Anjum Ansari, Bright Starling Emerald   +7 more
doaj   +1 more source

Elevated EBF2 in mouse but not pig drives the progressive brown fat lineage specification via chromatin activation

Journal of Advanced Research
Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis, but it is absent in some mammals, including pigs. During development, BAT progenitors are derived from paired box 7 (Pax7)-expressing somitic mesodermal stem cells, which also ...
Yinlong Liao, Zhelun Peng, Shanshan Fu, Yao Hua, Wenzhe Luo, Ruige Liu, Yingjin Chen, Wei Gu, Pengxiang Zhao, Jianguo Zhao, Yanfang Wang, Heng Wang   +11 more
doaj   +1 more source

CBP/p300-Interacting Transactivator, with Glu/Asp-Rich C-Terminal Domain, 2, and Pre-B-Cell Leukemia Transcription Factor 1 in Human Adrenal Development and Disease [PDF]

, 2008
Bruno Ferraz‐de‐Souza, Franziska Martin, Delphine Mallet, Rebecca E. Hudson‐Davies, Patricia Cogram, Lin Lin, Dianne Gerrelli, Felix Beuschlein, Yves Morel, Angela Huebner, John C. Achermann   +10 more
openalex   +1 more source

The relationship between factor inhibiting HIF-1-alpha (HIF1AN( expression and vascular invasion in colon cancer

The Journal of Qazvin University of Medical Sciences, 2016
Background: Hypoxia is a common phenomenon in human solid tumors which by increasing in angiogenesis induction cause tumor growth survival and metastasis. Inhibitory factor hypoxia regulatory factor (HIF1AN) by binding to transcription co activators
Reza Najafipour, Naser Rakhshani, Ladan Vakil, Farhad Zamani, Arman Morakabati, Amir Javadi   +5 more
doaj  

Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules [PDF]

, 1997
Valeria Facchinetti, Livio LOFFARELLI, Sabine Schreek, Michael Oelgeschläger, Bernhard Lüscher, Martino Introna, Josée Golay   +6 more
openalex   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science
Multiple myeloma (MM) is a plasma cell‐derived malignancy. While immune checkpoint blockade immunotherapy has advanced myeloma treatment, chemotherapy remains the primary therapy.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
doaj   +1 more source

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling [PDF]

, 2017
The human prolyl-4-hydroxylase domain (PHD) proteins 1-3 are known as cellular oxygen sensors, acting via the degradation of hypoxia-inducible factor (HIF) α-subunits.
Berchner-Pfannschmidt, Utta, Fandrey, Joachim, Hu, Jun, Kristiansen, Glen, Rehrauer, Hubert, Schraml, Peter, Stiehl, Daniel P., Wenger, Roland H., Wollenick, Kristin   +8 more
core  

Ser386 phosphorylation of transcription factor IRF‐3 induces dimerization and association with CBP/p300 without overall conformational change [PDF]

, 2010
Kiyohiro Takahasi, Masataka Horiuchi, Kiyonaga Fujii, Shingo Nakamura, Nobuo N. Noda, Mitsutoshi Yoneyama, Takashi Fujita, Fuyuhiko Inagaki   +7 more
openalex   +1 more source

cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1) [PDF]

, 1998
Eric S. Silverman, Jing Du, Amy J. Williams, Raj Wadgaonkar, Jeffrey M. Drazen, Tucker Collins   +5 more
openalex   +1 more source