Zinc-Induced Formation of a Coactivator Complex Containing the Zinc-Sensing Transcription Factor MTF-1, p300/CBP, and Sp1 [PDF]
Molecular and Cellular Biology, 2008 Herein, the mechanisms of transactivation of gene expression by mouse metal response element-binding transcription factor 1 (MTF-1) were investigated. Evidence obtained from coimmunoprecipitation assays revealed that exposure of the cells to zinc resulted in the rapid formation of a multiprotein complex containing MTF-1, the histone acetyltransferase ...
Yong, Li +4 more
openaire +3 more sources
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling. [PDF]
Brain BehavHistone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Mengistu DY, Eskeziyaw BM.
europepmc +2 more sources
PKCβΙΙ Augments NF-κB-Dependent Transcription at the CCL11 Promoter via p300/CBP-Associated Factor Recruitment and Histone H4 Acetylation [PDF]
The Journal of Immunology, 2008 Abstract The transcription factor NF-κB plays a pivotal role in regulating inflammatory gene expression. Its effects are optimized by various coactivators, including histone acetyltransferases (HATs) such as CREB-binding protein/p300 and p300/CBP-associated factor (p/CAF).
Deborah L, Clarke +5 more
openaire +3 more sources
Histone Lactylation Couples FSH-Driven Lactate Metabolism to Mitochondrial Biogenesis by Enhancing HDAC4-Mediated Deacetylation of PGC-1α in Granulosa Cells [PDF]
ResearchFollicle-stimulating hormone (FSH) coordinates ovarian follicle development by aligning mitochondrial biogenesis with increased metabolic demand. Although FSH is known to stimulate glycolysis in granulosa cells (GCs), the mechanism by which glycolytic ...
Gang Wu +13 more
doaj +2 more sources
Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors [PDF]
Frontiers in ImmunologyGlucose metabolic reprogramming describes the alterations in intracellular metabolic pathways in response to variations in the body’s internal environment. This metabolic reprogramming has been the subject of extensive research.
Yi Yang +17 more
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PLoS Pathogens, 2023 Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective ...
June F Yang, Wei Liu, Jianxin You
doaj +3 more sources
PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution
Nature Communications, 2023 Activation of oncogenic gene expression from long-range enhancers is initiated by the assembly of DNA-binding transcription factors (TF), leading to recruitment of co-activators such as CBP/p300 to modify the local genomic context and facilitate RNA ...
Yaw Asante +20 more
doaj +1 more source
Scientific Reports, 2023 The activation of stress response pathways in synovial fibroblasts (SF) is a hallmark of rheumatoid arthritis (RA). CBP and p300 are two highly homologous histone acetyl transferases and writers of activating histone 3 lysine 27 acetylation (H3K27ac ...
Monika Krošel +9 more
doaj +1 more source
Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region [PDF]
, 2012 Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies.
Daniel Öberg +7 more
core +12 more sources