TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition
Nature Communications, 2023 The histone acetyltransferase p300/CBP is composed of several conserved domains, among which, the TAZ2 domain is known as a protein-protein interaction domain that binds to E1A and various transcription factors.
Longxia Xu +8 more
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TRPM3-Induced Gene Transcription Is under Epigenetic Control
Pharmaceuticals, 2022 Transient receptor potential M3 (TRPM3) cation channels regulate numerous biological functions, including gene transcription. Stimulation of TRPM3 channels with pregnenolone sulfate activates stimulus-responsive transcription factors, which bind to short
Gerald Thiel, Oliver G. Rössler
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Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos. [PDF]
PLoS Genetics, 2012 CBP and the related p300 protein are widely used transcriptional co-activators in metazoans that interact with multiple transcription factors. Whether CBP/p300 occupies the genome equally with all factors or preferentially binds together with some ...
Per-Henrik Holmqvist +5 more
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eLife, 2021 Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of MYB transcriptional co-activator complex.
Sumiko Takao +13 more
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CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity
Cell Death and Disease, 2021 Loss of β cell identity and functional immaturity are thought to be involved in β cell failure in type 2 diabetes. CREB-binding protein (CBP) and its paralogue p300 act as multifunctional transcriptional co-activators and histone acetyltransferases (HAT)
Linlin Zhang +12 more
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Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. [PDF]
, 2015 Cyclooxygenase-2 (COX-2) plays an important role in lung cancer development and progression. Using streptavidin-agarose pulldown and proteomics assay, we identified and validated Ku80, a dimer of Ku participating in the repair of broken DNA double ...
Chen, Yiming +23 more
core +7 more sources
Natural Products with Antitumor Potential Targeting the MYB-C/EBPβ-p300 Transcription Module
Molecules, 2022 The transcription factor MYB is expressed predominantly in hematopoietic progenitor cells, where it plays an essential role in the development of most lineages of the hematopoietic system. In the myeloid lineage, MYB is known to cooperate with members of
Thomas J. Schmidt, Karl-Heinz Klempnauer
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The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53. [PDF]
PLoS ONE, 2008 BACKGROUND: The vaccinia-related kinase 1 (VRK1) protein, an activator of p53, can be proteolytically downregulated by an indirect mechanism, which requires p53-dependent transcription. PRINCIPAL FINDINGS: In this work we have biochemically characterized
Alberto Valbuena +3 more
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Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation
Frontiers in Cell and Developmental Biology, 2020 The protein kinase homeodomain-interacting protein kinase 2 (HIPK2) plays an important role in development and in the response to external cues. The kinase associates with an exceptionally large number of different transcription factors and chromatin ...
Jana Haas +9 more
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Acetylation reprograms MITF target selectivity and residence time
Nature Communications, 2023 The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis.
Pakavarin Louphrasitthiphol +15 more
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