Negative regulation of transcription coactivator p300 by orphan receptor TR3 [PDF]
, 2008 p300 regulates the transcriptional activity of a variety of transcription factors by forming an activation complex and/or promoting histone acetylation. Here, we show a unique characteristic of orphan receptor TR3 in negatively regulating the function of
Chen, Hang-Zi +9 more
core +1 more source
HTLV-1 bZIP factor: the key viral gene for pathogenesis
Retrovirology, 2020 Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in HTLV-1 infected cells and ATL cells.
Masao Matsuoka, Jean-Michel Mesnard
doaj +1 more source
Cell & Bioscience, 2023 Background How transcription factors (TFs) down-regulate gene expression remains ill-understood, especially when they bind to multiple enhancers contacting the same gene promoter. In particular, it is not known whether they exert similar or significantly
Fabienne Bejjani +6 more
doaj +1 more source
Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]
, 2019 BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda +5 more
core +5 more sources
Frontiers in Cellular and Infection Microbiology, 2017 Viral infection triggers a series of signaling cascades and host innate immune responses, including interferon (IFN) production, which depends on coordinated activity of multiple transcription factors.
Shengyu Wang +18 more
doaj +1 more source
Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family [PDF]
, 2014 We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase (HAT) domain of both p300
Lemasson, Isabelle +2 more
core +2 more sources
Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2. [PDF]
, 2015 CREB-binding protein (CBP) and p300 are transcriptional coactivators involved in numerous biological processes that affect cell growth, transformation, differentiation, and development. In this study, we provide evidence of the involvement of homeodomain-
Cardinaux, J.R. +4 more
core +2 more sources
PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins.
PLoS ONE, 2013 BackgroundLysine acetylation is an important post-translational modification that plays a central role in eukaryotic transcriptional activation by modifying chromatin and transcription-related factors. Human pregnancy-specific glycoproteins (PSG) are the
Soledad A Camolotto +4 more
doaj +1 more source
Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. [PDF]
PLoS ONE, 2013 Lysine acetyltransferases (KATs) play a unique role in regulating gene transcription as well as maintaining the epigenetic state of the cell. KATs such as Gcn5 and p300/CBP can modify multiple residues on a single histone; however, order and specificity ...
Yin-Ming Kuo, Andrew J Andrews
doaj +1 more source
Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]
, 2016 Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA +13 more
core +13 more sources