Results 81 to 90 of about 37,116 (209)

The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B [PDF]

, 2014
published_or_final_versio
Chan, SY, Chan, YS, Lai, SK, Li, Q, Liu, H, Mak, HS, McAlonan, GM, Ng, CP, Tsang, KH, Yung, WH   +9 more
core   +1 more source

Neem Leaf Glycoprotein Restrains VEGF Production by Direct Modulation of HIF1α-Linked Upstream and Downstream Cascades

Frontiers in Oncology, 2020
Neem Leaf Glycoprotein (NLGP) is a natural immunomodulator, have shown sustained tumor growth restriction as well as angiogenic normalization chiefly by activating CD8+ T cells.
Akata Saha, Partha Nandi, Shayani Dasgupta, Avishek Bhuniya, Nilanjan Ganguly, Tithi Ghosh, Ipsita Guha, Saptak Banerjee, Rathindranath Baral, Anamika Bose   +9 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Predicting Combinatorial Binding of Transcription Factors to Regulatory Elements in the Human Genome by Association Rule Mining [PDF]

, 2007
Cis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Although some cisregulatory elements have been well studied, the combinations of transcription
Iyer, Vishwanath R., Miranker, Daniel P., Morgan, Xochitl C., Ni, Sshulin   +3 more
core   +2 more sources

Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation

BMC Genomics, 2011
Background HIP1 Protein Interactor (HIPPI) is a pro-apoptotic protein that induces Caspase8 mediated apoptosis in cell. We have shown earlier that HIPPI could interact with a specific 9 bp sequence motif, defined as the HIPPI binding site (HBS), present ...
Lahiri Ansuman, Choudhury Ananyo, Datta Moumita, Bhattacharyya Nitai P   +3 more
doaj   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300 [PDF]

, 2011
It is well established that the coordinated regulation of activity-dependent gene expression by the histone acetyltransferase (HAT) family of transcriptional coactivators is crucial for the formation of contextual fear and spatial memory, and for ...
Baker-Andresen, Danay, Bredy, Timothy W., Coelho, Carlos M., Cole, Philip A., Dudley, Kevin J., Li, Xiang, Marek, Roger, Meyers, David, Mukherjee, Chandrani, Ratnu, Vikram, Sah, Pankaj, Sullivan, Robert K. P.   +11 more
core   +4 more sources

Expression of Adenoviral E1A in Transformed Cells as an Additional Factor of HDACi-Dependent FoxO Regulation

Cells, 2019
The adenoviral early region 1A (E1A) protein has proapoptotic and angiogenic activity, along with its chemosensitizing effect, making it the focus of increased interest in the context of cancer therapy.
Alisa Morshneva, Olga Gnedina, Tamara Marusova, Maria Igotti   +3 more
doaj   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes [PDF]

, 2008
journal ...
KATO Mitsuyasu, SUZUKI Hiroyuki, Wang Bei, 加藤 光保, 鈴木 裕之   +4 more
core   +1 more source