Results 121 to 130 of about 177,903 (366)

Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release

Journal of Ginseng Research, 2019
Background: Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic ...
Jung-Hae Shin, Hyuk-Woo Kwon, Man Hee Rhee, Hwa-Jin Park   +3 more
doaj  

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

Toxins, 2016
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2.
Dakshina M. Jandhyala, John Wong, Nicholas J. Mantis, Bruce E. Magun, John M. Leong, Cheleste M. Thorpe   +5 more
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway. [PDF]

, 2013
BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3.
Dholakia, S, Elkington, PT, Friedland, JS, Green, JA, Moores, R, Pezas, T, Rand, L   +6 more
core   +2 more sources

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Hyperthermia-mediated cell death via deregulation of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase signaling

Frontiers in Cell Death
Hyperthermia is a promising anticancer treatment that induces heat stress, thereby stimulating various signal transduction pathways to maintain cellular homeostasis.
Atsushi Enomoto, Takemichi Fukasawa, Takemichi Fukasawa, Ayumi Yoshizaki, Ayumi Yoshizaki   +4 more
doaj   +1 more source

Neuroprotective Effects of Tetrahydrocurcumin against Glutamate-Induced Oxidative Stress in Hippocampal HT22 Cells

Molecules, 2019
In the central nervous system, glutamate is a major excitable neurotransmitter responsible for many cellular functions. However, excessive levels of glutamate induce neuronal cell death via oxidative stress during acute brain injuries as well as chronic ...
Chang-Hyun Park, Ji Hoon Song, Su-Nam Kim, Ji Hwan Lee, Hae-Jeung Lee, Ki Sung Kang, Hyung-Ho Lim   +6 more
doaj   +1 more source

Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes [PDF]

, 2013
The health effects arising from exposure to low doses of ionizing radiation are of particular concern, mainly due to the increased application of diagnostic and therapeutic X-ray modalities.
Baatout, Sarah, El Saghire, Houssein, Michaux, Arlette, Thierens, Hubert   +3 more
core   +1 more source

Underlying Mechanism of Jiuwei Shengmai Powder in Improving Myocardial Hypoxia at High Altitude Based on Network Pharmacology and Molecular Docking

iLABMED, EarlyView.
The expression pathway of COX and the downstream mechanism of PGE. M: muscarinic receptor; PL: phospholipid; PLA2: phospholipase A2; AA: arachidonic acid; EP1: prostaglandin E1 receptor; EP2: prostaglandin E2 receptor; EP3: prostaglandin E3 receptor; EP4: prostaglandin E4 receptor.
Cong Wu, Yanjuan Zhu, Changpeng Xie, Haobo Liu, Yuanming Pan, Chang'e Liu   +5 more
wiley   +1 more source

Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line

Poultry Science, 2020
Defensins are antimicrobial peptides composed of 3 conserved disulfide bridges, a β-sheet, and both hydrophobic and cationic amino acids. In this study, we aimed to demonstrate the immunomodulation role of avian β-defensin 8 (AvBD8) in a chicken ...
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong   +5 more
doaj