Results 121 to 130 of about 183,974 (371)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-Activated Protein Kinases

Journal of Pharmacological Sciences, 2003
Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective.
Masanori Yoshizumi, Jun-ichi Abe, Koichiro Tsuchiya, Bradford C. Berk, Toshiaki Tamaki   +4 more
doaj   +1 more source

ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. [PDF]

, 2015
Backgrounds and aims4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes.
Casanova, James E, Castillo, Victoria, Choudhury, Sarmistha Sinha, Das, Soumita, Eckmann, Lars, Elliott, Michael R, Ernst, Peter B, Fox, Sarah, Owen, Katherine A, Sarkar, Arup   +9 more
core  

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Journal of signal transduction, 2011
Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases that play the major role in signal transduction from the cell surface to the nucleus.
Yong Son, Y. Cheong, Nam‐Ho Kim, Hun-taeg Chung, D. Kang, H. Pae   +5 more
semanticscholar   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Major Differences in Hypoxia Tolerance and P38 Regulation Among Different Renal Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mitogen-activated protein kinases (MAPKs) are involved in the cellular response to hypoxia and their dysregulation may contribute to the progression and pathology of diverse human renal diseases.
Qianqian Shi, Jian Shi, Fengbao Luo, Guanglai Song, Xiaozhou He, Ying Xia   +5 more
doaj   +1 more source

Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]

, 2015
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, Mark C, Baashen, Mohammed, Chuckowree, Irina, Dwyer, Jessica E, Kipling, David, Davis, Terence   +5 more
core   +3 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Emerging roles of the mitogen and stress activated kinases MSK1 and MSK2 [PDF]

, 2016
Mitogen- and stress-activated kinases (MSK) 1 and 2 are nuclear proteins activated downstream of the ERK1/2 or p38 MAPK pathways. MSKs phosphorylate multiple substrates, including CREB and Histone H3, and their major role is the regulation of specific ...
Aksentijevich, Alberini, Alcacer, Ananieva, Arthur, Arthur, Arthur, Baroncelli, Benito, Bertelsen, Besnard, Bilang-Bleuel, Brami-Cherrier, Brami-Cherrier, Brindle, Brook, Brooks, Bruck, Caenepeel, Cardinaux, Carlezon, Chakraborty, Chandramohan, Chang, Cheng, Cheng, Choi, Chrivia, Chwang, Chwang, Clark, Corrêa, Cowansage, D'Hooge, Darragh, Davis, Day, De Pablo, Deak, Dong, Elcombe, Feyder, Funding, Funding, Garlanda, Gesser, Gonzalez, Hargett, Impey, Jin, Johannessen, Kandel, Karelina, Kasper, Kew, Kim, Korte, Kühn, Lang, Levenson, Liu, Lonze, MacKenzie, MacKenzie, Manto, Martin, Martin, Mayer, Mayr, Mayr, McCoy, McCoy, Mifsud, Naqvi, New, Park, Peng, Pierrat, Pérez-Cadahía, Raab-Traub, Rahman, Reeves, Remenyi, Remenyi, Reyes, Roizman, Roze, Rutherford, Sakamoto, Salgado, Shah, Shaywitz, Sindreu, Singh, Soloaga, Taubenfeld, Taylor, Turrigiano, Venkatesh, Vermeulen, Walker, Wang, Wang, Wayman, West, Wiggin, Yamamoto   +106 more
core   +2 more sources

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ*

Journal of Biological Chemistry, 1997
We have cloned and characterized a new member of the p38 group of mitogen-activated protein kinases here termed p38δ. Sequence comparisons revealed that p38δ is approximately 60% identical to the other three p38 isoforms but only 40–45% to the other ...
Yong Jiang, H. Gram, Ming-zhe Zhao, L. New, J. Gu, Lili Feng, F. D. Di Padova, R. Ulevitch, Jiahuai Han   +8 more
semanticscholar   +1 more source