P38 mitogen-activated protein kinases

Science, 2002
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another.
G. Johnson, R. Lapadat
semanticscholar +3 more sources

p38 mitogen-activated protein kinase and pain

Life Sciences, 2020
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain.
Lijia, Mai +4 more
openaire +2 more sources

p38 Mitogen-Activated Protein Kinase Regulates Myelination

Journal of Molecular Neuroscience, 2007
The p38 mitogen-activated protein kinase family is emerging as a crucial signaling molecule for a vast number of cellular functions including cell migration, proliferation, and differentiation. The function of p38 in myelination has only been recently addressed.
Jeffery D, Haines +4 more
openaire +2 more sources

p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

Mini-Reviews in Medicinal Chemistry, 2006
The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
J, Westra, P C, Limburg
openaire +4 more sources

kinase
protein kinase a
cell biology

chemistry
biochemistry
mapk/erk pathway

mitogen-activated protein kinase
molecular biology
signal transduction