Results 321 to 330 of about 177,903 (366)

Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation

Journal of Receptors and Signal Transduction, 2004
The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Kanako Sakurai, Yoshitoshi Kasuya, Yoh Takuwa, Yuji Matsuo, Tatsuhiko Sudo, Sadao Kimura   +5 more
openaire   +3 more sources

Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts [PDF]

Vascular and Endovascular Surgery, 2008
Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers and n-fb from the ipsilateral thigh.
Kristen C. Overman, James O. Menzoian, Christopher H. Gram, Joseph D. Raffetto   +3 more
openaire   +2 more sources

Isoflurane preconditioning induces neuroprotection against ischemia via activation of P38 mitogen-activated protein kinases.

Molecular Pharmacology, 2004
A brief exposure to the volatile anesthetic isoflurane (preconditioning) induces ischemic tolerance in rat brain. However, whether isoflurane preconditioning improves long-term neurological outcome after brain ischemia and the mechanisms for this ...
Shuqiu Zheng, Zhiyi Zuo
semanticscholar   +1 more source

Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease.

Journal of Molecular and Cellular Cardiology, 1999
Three well-characterized mitogen-activated protein kinase (MAPK) subfamilies are expressed in rodent and rabbit hearts, and are activated by pathophysiological stimuli. We have determined and compared the expression and activation of these MAPKs in donor
S. Cook, P. Sugden, A. Clerk
semanticscholar   +1 more source

Analyzing JNK and p38 mitogen-activated protein kinase activity

2001
Publisher Summary The JNK and p38 mitogen-activated protein (MAP) kinase groups are important for many physiological processes including cell growth, oncogenic transformation, cell differentiation, apoptosis, and the immune response. To understand the role of JNK and p38 MAP kinases in the cell, several protocols for measuring their activation state ...
Whitmarsh, A. J., Davis, R. J.
openaire   +4 more sources

Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
Dehydroepiandrosterone-sulfate, the sulfated form of dehydroepiandrosterone, is the most abundant steroid in young adults, but gradually declines with aging. In humans, the clinical application of dehydroepiandrosterone targeting some collagen diseases, such as systemic lupus erythematosus, as an adjunctive treatment has been applied in clinical trial.
Kiminobu Goto, Toshihiko Yanase, Taijiro Okabe, Masatoshi Nomura, Yue Zhao, Kenji Ashida, Ryoichi Takayanagi, Hajime Nawata   +7 more
openaire   +3 more sources

Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.

Blood, 2000
Eotaxin and other CC chemokines acting via CC chemokine receptor-3 (CCR3) are believed to play an integral role in the development of eosinophilic inflammation in asthma and allergic inflammatory diseases. However, little is known about the intracellular
G. Kampen, S. Stafford, T. Adachi, Jinquan Tan, S. Quan, J. Grant, P. Skov, L. Poulsen, R. Alam   +8 more
semanticscholar   +1 more source

Activation of p38 Mitogen-activated Protein Kinase in Rat Periapical Lesions

Journal of Endodontics, 2008
The purpose of this study was to investigate the activation of p38 mitogen-activated protein kinase (MAPK) during the development of periapical lesions in rats. Periapical lesions developed within 28 days after pulp exposure of mandibular first molars in Wistar rats.
Rui Zhang, Bin Peng, Li Wang
openaire   +3 more sources

Inhibitors of p38 Mitogen-Activated Protein Kinase

BioDrugs, 2003
Asthma is an inflammatory disease of the airways, which in patients with mild to moderate symptoms is adequately controlled by either beta(2)-adrenoceptor agonists or corticosteroids, or a combination of both. Despite this, there are classes of patients that fail to respond to these treatments.
Neil S. Holden, Robert Newton, Robert Newton   +2 more
openaire   +3 more sources

Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice

Journal of Trauma and Acute Care Surgery, 2012
Patients with multiple injuries surviving the initial insult are highly susceptible to secondary pneumonia, frequently progressing into sepsis and multiorgan failure. However, the underlying mechanisms of posttraumatic immunosuppression are poorly understood.
Katja Dahlke, Ulrich A. Maus, Jennifer Bohling, Petra C. Mailer, Tobias Welte, Niels C. Riedemann, Regina Maus, Michael Bauer, Ann-Kathrin Janze, Nadine Ding   +9 more
openaire   +3 more sources