Results 331 to 340 of about 183,974 (371)

Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation

Journal of Receptors and Signal Transduction, 2004
The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Kanako, Sakurai, Yuji, Matsuo, Tatsuhiko, Sudo, Yoh, Takuwa, Sadao, Kimura, Yoshitoshi, Kasuya   +5 more
openaire   +2 more sources

Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts

Vascular and Endovascular Surgery, 2008
Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers and n-fb from the ipsilateral thigh.
Joseph D, Raffetto, Christopher H, Gram, Kristen C, Overman, James O, Menzoian   +3 more
openaire   +2 more sources

p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

Pharmacology & Therapeutics, 1999
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be selective inhibitors for p38 mitogen-activated protein kinase (MAPK), a member of the MAPK family.
J C, Lee, S, Kassis, S, Kumar, A, Badger, J L, Adams   +4 more
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Analyzing JNK and p38 mitogen-activated protein kinase activity

2001
Publisher Summary The JNK and p38 mitogen-activated protein (MAP) kinase groups are important for many physiological processes including cell growth, oncogenic transformation, cell differentiation, apoptosis, and the immune response. To understand the role of JNK and p38 MAP kinases in the cell, several protocols for measuring their activation state ...
Whitmarsh, A. J., Davis, R. J.
openaire   +3 more sources

Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
Dehydroepiandrosterone-sulfate, the sulfated form of dehydroepiandrosterone, is the most abundant steroid in young adults, but gradually declines with aging. In humans, the clinical application of dehydroepiandrosterone targeting some collagen diseases, such as systemic lupus erythematosus, as an adjunctive treatment has been applied in clinical trial.
Kenji, Ashida, Kiminobu, Goto, Yue, Zhao, Taijiro, Okabe, Toshihiko, Yanase, Ryoichi, Takayanagi, Masatoshi, Nomura, Hajime, Nawata   +7 more
openaire   +2 more sources

Inhibitors of p38 Mitogen-Activated Protein Kinase

BioDrugs, 2003
Asthma is an inflammatory disease of the airways, which in patients with mild to moderate symptoms is adequately controlled by either beta(2)-adrenoceptor agonists or corticosteroids, or a combination of both. Despite this, there are classes of patients that fail to respond to these treatments.
Robert, Newton, Neil, Holden
openaire   +2 more sources

Structure-Activity Relationships of p38 Mitogen-Activated Protein Kinase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2005
Rheumatoid arthritis and other chronic inflammatory diseases constitute a major therapeutic challenge, usually not sufficiently met by the classical antiinflammatory medications. Recent research efforts provided new insights into the molecular basis of these pathologies and disclosed new opportunities for developing improved drugs directed to the ...
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p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

Chest, 2011
The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals. Of the four isoforms, p38α is the most abundant in inflammatory cells and has been the most studied through mainly the availability of ...
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Activation of p38 Mitogen-activated Protein Kinase in Rat Periapical Lesions

Journal of Endodontics, 2008
The purpose of this study was to investigate the activation of p38 mitogen-activated protein kinase (MAPK) during the development of periapical lesions in rats. Periapical lesions developed within 28 days after pulp exposure of mandibular first molars in Wistar rats.
Rui, Zhang, Li, Wang, Bin, Peng
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Effectors—Sonic Hedgehog and p38 Mitogen-Activated Protein Kinase

2008
This chapter covers the identification of mitogen-activated protein kinases as early stage transducers of the damaging effects of glucose on peripheral nerves. They are activated by several metabolic consequences of hyperglycemia, in particular oxidative stress, osmotic stress, and advanced glycation end products.
Sally A. Price, Rebecca C. Burnand, David R. Tomlinson   +2 more
openaire   +1 more source