Results 331 to 340 of about 177,903 (366)

p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

Chest, 2011
The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals. Of the four isoforms, p38α is the most abundant in inflammatory cells and has been the most studied through mainly the availability of ...
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p38 Mitogen-activated protein kinase expression and activation in smooth muscle

American Journal of Physiology-Cell Physiology, 1998
There is relatively little known about expression and activation of p38 mitogen-activated protein kinases (MAPKs) through G protein-linked, seven-transmembrane-spanning (STM) receptors in mammalian smooth muscle. To investigate the role of p38 MAPK in smooth muscle, we cloned and sequenced the p38 MAPK expressed in canine smooth muscles. A full-length
Ilia A. Yamboliev, Burton Horowitz, Leonard P. Adam, Jason C. Hedges, William T. Gerthoffer, Mai Ngo   +5 more
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The p38 Mitogen-Activated Protein Kinase Pathway in Interferon Signal Transduction

Journal of Interferon & Cytokine Research, 2005
Interferons (IFNs) are cytokines that regulate a variety of biologic effects, including cellular antiviral responses, inhibition of proliferation, induction of differentiation, and immunoregulation, via different mechanisms. In order to mediate such pleiotropic effects, IFNs trigger numerous signaling events.
Yongzhong Li, Heather Mears, Leonidas C. Platanias, Efstratios Katsoulidis   +3 more
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Structure-Activity Relationships of p38 Mitogen-Activated Protein Kinase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2005
Rheumatoid arthritis and other chronic inflammatory diseases constitute a major therapeutic challenge, usually not sufficiently met by the classical antiinflammatory medications. Recent research efforts provided new insights into the molecular basis of these pathologies and disclosed new opportunities for developing improved drugs directed to the ...
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Involvement of the p38 mitogen‐activated protein kinase cascade in hepatocellular carcinoma

Cancer, 2003
AbstractBACKGROUNDThe mitogen‐activated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma (HCC) tissue specimens.METHODSConstitutively active mutant of ...
Jiro Fujimoto, Tetsuo Takehara, Mitsuru Sakakibara, Kenya Iyoda, Masayoshi Horimoto, Yutaka Sasaki, Norio Hayashi, Takayuki Yakushijin, Takashi Toyama, Masatsugu Hori, Jack R. Wands   +10 more
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p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

Pharmacology & Therapeutics, 1999
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be selective inhibitors for p38 mitogen-activated protein kinase (MAPK), a member of the MAPK family.
Shouki Kassis, Sanjay Kumar, Jerry L. Adams, John C. Lee, Alison M. Badger   +4 more
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Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion.

Circulation Research, 1996
It has recently been recognized that cellular stresses activate certain members of the mitogen-activated protein kinase (MAPK) superfamily. One role of these "stress-activated" MAPKs is to increase the transactivating activity of the transcription ...
M. Bogoyevitch, J. Gillespie-Brown, A. Ketterman, S. Fuller, R. Ben-Levy, Alan Ashworth, C. Marshall, P. Sugden   +7 more
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Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor

Nature Chemical Biology, 2011
Until now, a lack of inhibitors with high potency and selectivity in vivo has hampered investigation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We describe the design of skepinone-L, which is, to our knowledge, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L
Stefan Laufer, Andreas Koeberle, Wolfgang Albrecht, Thilo Stehle, Thilo Stehle, Christian Grütter, Johannes Romir, Daniel Rauh, Verena Schattel, Solveigh C. Koeberle, Solveigh C. Koeberle, Stefan Fischer, Oliver Werz   +12 more
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Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1

Cellular Signalling, 2007
The members of the transcription factor Foxo family regulate the expression of genes concerned with the stress response, cell cycle and gluconeogenesis. Foxo1 (FKHR) contains 15 consensus phosphorylation sites for the mitogen-activated protein kinase (MAPK) family.
Tsutomu Kishi, Hidehito Mukai, Tatsuhiko Sudo, Hitomi Matsuzaki, Tomoko Saito, Koichiro Kako, Akiyoshi Fukamizu, Hiroaki Daitoku, Shintaro Iwashita, Sachie Asada, Yoshitoshi Kasuya   +10 more
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Hierarchy of eosinophil chemoattractants: role of p38 mitogen‐activated protein kinase

European Journal of Immunology, 2006
AbstractSeveral chemoattractants can regulate the recruitment of eosinophils to sites of inflammation, but the hierarchy among them is unknown. We observed here that eosinophil chemotaxis towards eotaxin or 5‐oxo‐6,8,11,14‐eicosatetraenoic acid (5‐oxo‐ETE) was amplified up to sixfold in the presence of prostaglandin (PG) D2.
Julia F. Royer, Eva M. Sturm, Gunter J. Sturm, Irmgard Th. Lippe, Akos Heinemann, Akos Heinemann, Petra Schratl, Bernhard A. Peskar   +7 more
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