Results 181 to 190 of about 342,417 (266)

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Ciliated Cells Drive Critical STING-Mediated Tumor Suppression in the Fallopian Tube Epithelium. [PDF]

Cancer Res
Colina JA, Recouvreux MS, Sobeck AM, Johnson BK, Lin Y, Sekhar SC, Avelar RA, Rivera-Gonzalez G, Zhai Y, Ram H, Fatima A, DiBenedetto P, Baldassarre J, McIntyre G, Teitel J, Dziubinski ML, Puleo N, Miglo J, Bedi K, Shen H, Thomas D, Huvila J, Cochrane DR, Drapkin R, Lei YL, Burdette JE, Skala SL, Huntsman DG, Cho KR, Orsulic S, DiFeo A.   +30 more
europepmc   +1 more source

Correction to “Evolution and Domestication of a Novel Biosynthetic Gene Cluster Contributing to the Flavonoid Metabolism and High‐Altitude Adaptability of Plants in the Fagopyrum Genus”

Advanced Science, EarlyView.
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

The CHK1 inhibitor Prexasertib is effective against <i>in vitro</i> models of aggressive thyroid carcinomas with defective p53 function. [PDF]

Front Endocrinol (Lausanne)
Manzo A, Grassi ES, Borghi MO, Colombo C, Persani L, Cirello V.   +5 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Naringenin inhibited vascular calcification and attenuated senescence-associated changes through the p53/TOP2Aaxis. [PDF]

Front Pharmacol
Tong X, Zhao M, Hu Y, Zhang Q, He R, Yan R.   +5 more
europepmc   +1 more source

p53 [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Follicular fluid-derived exosomal LINC02701 promotes granulosa cell apoptosis through the GRP75-P53 axis in active endometriosis. [PDF]

Front Cell Dev Biol
Zhou F, Tang X, Li K, Lu N, Mao Y.
europepmc   +1 more source