Results 21 to 30 of about 651,566 (203)

Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle

British Journal of Pharmacology, Volume 179, Issue 24, Page 5273-5289, December 2022., 2022
Background and Purpose Donepezil, a piperidine inhibitor of acetylcholinesterase (AChE) prescribed for treatment of Alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non‐depolarising neuromuscular blockers during surgery.
Robert R. Redman, Harry Mackenzie, Kosala N. Dissanayake, Michael Eddleston, Richard R. Ribchester   +4 more
wiley   +1 more source

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity

ChemMedChem, Volume 17, Issue 18, September 16, 2022., 2022
Substrate mimicry: Substrate peptidomimetics were designed and showed potent inhibition of plasmepsin X (PMX). The peptidomimetics block PMX ligand processing, arrest asexual parasites at the schizont stage and potently kill P. falciparum parasites. The peptidomimetics will further assist in the understanding of PMX selectivity and in the development ...
Lachlan W. Richardson, Trent D. Ashton, Madeline G. Dans, Nghi Nguyen, Paola Favuzza, Tony Triglia, Anthony N. Hodder, Anna Ngo, Kate E. Jarman, Alan F. Cowman, Brad E. Sleebs   +10 more
wiley   +1 more source

Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis

European Respiratory Journal, 2021
Drug susceptibility testing of M. tuberculosis is rooted in a binary susceptible/resistant paradigm. While there are considerable advantages in measuring the minimum inhibitory concentrations (MICs) of a panel of drugs for an isolate, it is necessary to ...
P. Fowler
semanticscholar   +1 more source

Framing young children’s humour and practitioner responses to it using a Bakhtinian carnivalesque lens [PDF]

, 2015
This article presents findings from a pilot study offering an alternative framing of children’s humour and laughter in an early childhood education setting. It employs a Bakhtinian carnivalesque lens to explore the nature of children’s humour in an urban
Jennings-Tallant, L
core   +3 more sources

PENGELOLAAN DANA KEMAHASISWAAN: KECURANGAN DAN MODUS MELAKUKANNYA [PDF]

, 2022
ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan modus kecurangan dalam pengelolaan dana kemahasiswaan yang berpotensi menghambat terwujudnya akuntabilitas dalam Good University Governance (GUG).
Damayanti, Rhosalina, Hapsari, Aprina Nugrahesthy Sulistya, Rompis, Adrian Izaak   +2 more
core   +1 more source

Piezoelectric Polymeric Foams as Flexible Energy Harvesters: A Review

Advanced Energy and Sustainability Research, Volume 3, Issue 9, September 2022., 2022
Advances in conventional and recent polymeric foam‐based piezoelectrics considering their various generation technology and various polymer systems are summarized for energy‐harvesting applications. Piezoelectric energy harvesters (PEHs) have the potential to power low‐power electronic devices and can advance, self‐powered, autonomous electronics to ...
Manauwar Ali Ansari, Patcharapon Somdee
wiley   +1 more source

Week 96 extension results of a Phase 3 study evaluating long-acting cabotegravir with rilpivirine for HIV-1 treatment

AIDS (London), 2021
Supplemental Digital Content is available in the text Background: ATLAS (NCT02951052), a phase 3, multicenter, open-label study, demonstrated that switching to injectable cabotegravir (CAB) with rilpivirine (RPV) long-acting dosed every 4 weeks was ...
S. Swindells, T. Lutz, L. van Zyl, N. Porteiro, M. Stoll, E. Mitha, A. Shon, P. Benn, Jenny Huang, Conn M. Harrington, K. Hove, S. Ford, C. Talarico, V. Chounta, H. Crauwels, R. V. Van Solingen-Ristea, S. Vanveggel, D. Margolis, Kimberly Smith, Kati Vandermeulen, W. Spreen   +20 more
semanticscholar   +1 more source

PI3Kγ is a novel regulator of TNFα signaling in the human colon cell line HT29/B6

Annals of the New York Academy of Sciences, Volume 1515, Issue 1, Page 196-207, September 2022., 2022
We evaluated the role of class I PI3Kγ in the setting of TNFα‐mediated barrier breakdown in human HT‐29/B6 colon carcinoma cells by comparing wild‐type and PI3Kγ catalytic subunit–deficient cells. We provide evidence that loss of PI3Kγ in HT‐29/B6 cells affects basal regulation of claudin‐2, and that the scaffolding function of PI3Kγ mediates the ...
Franz‐Leonard Klaus, Cornelia Kirsch, Jörg P. Müller, Otmar Huber, Juliane Reiche   +4 more
wiley   +1 more source

Clinical profiles of subsequent stages in bipolar disorder: Results from the Dutch Bipolar Cohort

Bipolar Disorders, Volume 24, Issue 4, Page 424-433, June 2022., 2022
Abstract Introduction The manifestation of bipolar disorder (BD) is hypothesized to be determined by clinical characteristics such as familial loading, childhood abuse, age at onset, illness duration, comorbid psychiatric disorders, addiction, treatment resistance, and premorbid cognitive functioning.
Afra van der Markt, Ursula M. H. Klumpers, Annemiek Dols, Marco P. Boks, Annabel Vreeker, Aartjan T. F. Beekman, Ralph W. Kupka   +6 more
wiley   +1 more source

IntAct: A 96-Core Processor With Six Chiplets 3D-Stacked on an Active Interposer With Distributed Interconnects and Integrated Power Management

IEEE Journal of Solid-State Circuits, 2021
In the context of high-performance computing, the integration of more computing capabilities with generic cores or dedicated accelerators for artificial intelligence (AI) application is raising more and more challenges.
P. Vivet, Eric Guthmuller, Y. Thonnart, G. Pillonnet, César Fuguet, I. Miro-Panades, G. Moritz, J. Durupt, C. Bernard, D. Varreau, Julian J. H. Pontes, S. Thuries, David Coriat, M. Harrand, D. Dutoit, D. Lattard, L. Arnaud, J. Charbonnier, P. Coudrain, A. Garnier, F. Berger, A. Gueugnot, A. Greiner, Quentin L. Meunier, A. Farcy, A. Arriordaz, S. Chéramy, F. Clermidy   +27 more
semanticscholar   +1 more source