Results 31 to 40 of about 26,604,708 (146)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Some inequalities for (p,q) $(p,q)$-mixed volume
, 2018 Lutwak, Yang, and Zhang introduced the concept of (p,q) $(p,q)$-mixed volume whose special cases contain the Lp $L_{p}$-mixed volume and the Lp $L_{p}$-dual mixed volume.
Bin Chen, Weidong Wang
core +1 more source
q-Differential equations for q-classical polynomials and q-Jacobi-Stirling numbers [PDF]
, 2016 We introduce, characterise and provide a combinatorial interpretation for the so-called q-Jacobi–Stirling numbers. This study is motivated by their key role in the (reciprocal) expansion of any power of a second order q-differential operator having the
Zeng, Jiang +5 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Relevant Functions to (p,q)-Gamma Function and (p,q)-Beta Function
, 2019 In this article, we study some new functions (namely Γ ̃_(p,q) (z)=Γ_(q/p) (z) and B ̃_(p,q) (s,t)=Γ_(q/p) (s,t)) and we will show how these functions are relevant to (p,q)-Gamma function and (p,q)-Beta ...
Areen Al-Khateeb
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Quantile-quantile (Q-Q) plot of the observed GWAS p-values (−log10P).
, 2012 Quantile-quantile (Q-Q) plot of the observed GWAS p-values (−log10P).
Ann-Charlotte Iversen (178510) +18 more
core +1 more source
Q-Q plot of p-values for Liver tissue in LDL and T2D TWAS.
, 2022 Here we display the Q-Q plot of p-values before and after controlling for genomic inflation in our Liver-LDL and liver-T2D TWAS. The LDL plot suggests an enrichment in signals due to high power in the original GWAS analysis. (PDF)
Hyun Min Kang (9690325) +1 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Existence and regularity for elliptic equations under p,q-growth
, 2014 Under general p,q-growth conditions, we prove that the Dirichlet problem \[\sum_{i=1}^{n}D_{x_{i}}(a^{i}(x,Du))=b(x) \text{in}\,\Omega , u=u_{0} \text{on}\,\partial \Omega\] has a weak solution $u\in W_{loc}^{1,q}(\Omega)$ under the assumptions ...
CUPINI, GIOVANNI +2 more
core