Results 41 to 50 of about 26,604,708 (146)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Spherical Functions on SO0(p, q) / SO(p) × SO(q)

, 2014
. An integral formula is derived for the spherical functions on the symmetric space G/K = SO0(p, q) / SO(p) × SO(q). This formula allows us to state some results about the analytic continuation of the spherical functions to a tubular neighbourhood of ...
P. Sawyer
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Variational method to a fractional impulsive (p,q) $(p,q)$-Laplacian coupled systems with partial sub- (p,q) $(p,q)$ linear growth

, 2019
In this paper, by using the least action principle, an existence result of nontrivial weak solutions for a class of fractional impulsive coupled systems with (p,q) $(p,q)$-Laplacian is obtained if the nonlinear term has sub- (p,q) $(p,q)$ linear growth ...
Xingyong Zhang, Cuiling Liu, Junping Xie
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The second Hyper-Zagreb index of VC5C7 [p, q] and HC5C7 [p, q] nanotubes

The first and second Hyper-Zagreb indices are the molecular descriptors that describe the structures of chemical compounds and they help us to predict certain physicochemical properties. In this paper, we studied the first and second Hyper-Zagreb indices
ZEREN, Yusuf, Alameri, Abdu Q., Alsharafi, Mohammed S. Y.   +2 more
core   +1 more source

A certain ( p , q ) $(p,q)$ -derivative operator and associated divided differences [PDF]

, 2016
Recently, Sofonea (Gen. Math. 16:47-54, 2008) considered some relations in the context of quantum calculus associated with the q-derivative operator D q $D_{q}$ and divided difference. As applications of the post-quantum calculus known as the ( p , q ) $(
Araci, Serkan, Mehmet Acikgoz, Duran, Ugur, Hari M Srivastava, Serkan Araci, Acikgoz, Mehmet, Uğur Duran, Srivastava, H. M.   +7 more
core   +1 more source