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P. aeruginosa Biofilms in CF Infection [PDF]
Clinical Reviews in Allergy and Immunology, 2008 Pseudomonas aeruginosa is an opportunistic pathogen of immunocompromised hosts. In cystic fibrosis (CF), P. aeruginosa causes acute and chronic lung infections that result in significant morbidity and mortality. P. aeruginosa possesses several traits that contribute to its ability to colonize and persist in acute and chronic infections.
Victoria E Wagner, Barbara H Iglewski
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Nanoscale effects of antibiotics on P. aeruginosa
Nanomedicine: Nanotechnology, Biology and Medicine, 2012Studying living bacteria at the nanoscale in their native liquid environment opens an unexplored landscape. We focus on Pseudomonas aeruginosa and demonstrate how the cell wall is biophysically affected at the nanoscale by two reference antibiotics (ticarcillin and tobramycin).
Formosa-Dague, Cécile +3 more
openaire +4 more sources
P. aeruginosa quorum-sensing systems and virulence
Current Opinion in Microbiology, 2003Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence.
Roger S, Smith, Barbara H, Iglewski
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P. aeruginosa biofilm activates the NLRP3 inflammasomes in vitro
Microbial Pathogenesis, 2022The ability of P.aeruginosa to form biofilms renders common treatments inefficient, thereby promoting chronic infection. Inflammasomes activate caspase-1, which is important for the maturation of IL-1β and IL-18 and evoke an inflammatory response. We aimed to investigate the activation of inflammasomes induced by P.aeruginosa biofilm.
Qi, Tan +4 more
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Acquired Resistance to P. aeruginosa
1993Infections due to Pseudomonas aeruginosa are difficult to acquire without a basic underlying condition such as immunosuppression or cystic fibrosis (CF). Innate resistance to this organism is high. Community-acquired infection is rare, limited mostly to non-life-threatening conditions such as folliculitis from a hot tub or whirlpool and otitis externa.
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International Journal of Antimicrobial Agents, 1992
Mice fed 0 serotype-specific strains of P. aeruginosa for two weeks, had increased titers of IgM but not IgG antibodies to the strains fed. Immunized mice, burned and infected with P. aeruginosa, showed significant 0 serotype-specific enhanced survival.
I A, Holder, M, Orloff, A N, Neely
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Mice fed 0 serotype-specific strains of P. aeruginosa for two weeks, had increased titers of IgM but not IgG antibodies to the strains fed. Immunized mice, burned and infected with P. aeruginosa, showed significant 0 serotype-specific enhanced survival.
I A, Holder, M, Orloff, A N, Neely
openaire +2 more sources
DNA aptamers targeting P. aeruginosa RNAP
Chemical CommunicationsWe present the first DNA aptamers designed to target the RNA polymerase (RNAP) of Pseudomonas aeruginosa .
Hari Timilsina +8 more
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