Results 171 to 180 of about 5,197,105 (317)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Mixed collocation methods for y” = f(x , y) [PDF]
, 1999 The second-order initial value problem y" = f(x,y), y(x(_0)) = y(_0), y'(x(_0)) = z(_0) which does not contain the first derivative explicitly and where the solution is oscillatory has been of great interest for many years.
Duxbury, S.C., Duxbury, Suzanne Claire
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Unique continuation for solutions of \(p(x)\)-Laplacian equations
Electronic Journal of Differential Equations, 2012 Summary: We study the unique continuation property for solutions to the quasilinear elliptic equation \[ \text{div}(|\nabla u|^{p(x)-2}\nabla u) +V(x)|u|^{p(x)-2}u=0\quad \text{in }\Omega, \] where \(\Omega\) is a smooth bounded domain in \(\mathbb{R}^N\) and ...
Johnny Cuadro, Gabriel Lopez G.
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The RMSM-S+P : a minimal poverty module for the RMSM-X [PDF]
The authors present a new tool, the RMSM-X+P, which essentially consists of a RMSM-X model with an additional module for poverty and social indicators. This linkage facilitates the analysis of the impact of various macroeconomic shocks on a selected set ...
Ranaweera,Thilakaratna +2 more
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Study of Riesz’s kernel associated to the symbol hxi = max{|x|p, pγ}. [PDF]
, 2018 Esta tesis está dedicada al estudio de la transformada de Fourier k_α del símbolo ⟨x⟩=máx{|x|_p,p^γ }. Se muestra que la familia de núcleos, k_α, forman un semigrupo de convolución con el fin de encontrar soluciones fundamentales para la ecuación ...
Pedraza Prieto, Carlos Jhovany
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Metabolic Fingerprinting on a Plasmonic Gold Chip for Mass Spectrometry Based in Vitro Diagnostics
ACS Central Science, 2018 Xuming Sun +11 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The hyperspaces C(p,X) for atriodic continua [PDF]
, 2005 Let C(X) denote the hyperspace of subcontinua of a continuum X. For A is an element of C(X), define the hyperspace C(A, X) = {B is an element of C(X) : A subset of B}.
Pellicer-Covarrubias, P
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