Results 51 to 60 of about 108,013 (309)
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan +11 more
wiley +1 more source
Constructing Seamless Interfaces for Ultrastable Flexible Supercapacitors
Advanced Science, EarlyView.Seamless electrode/electrolyte and electrolyte/electrolyte interfaces with boosted interfacial toughness and adhesion are constructed by anchored interfacial polymerization and in situ polymerization, respectively. The achieved supercapacitor exhibits ultrahigh capacitance retention over 100,000 times of charge/discharge or folding deformation ...
Keyi Dong +8 more
wiley +1 more source
Revista de Arqueologia, 2013 A expansão desenfreada do grande capital pelo país segue deixando comunidades locais, já marginalizadas, em situações ainda mais precárias. O presente artigo (Manifesto1) traz uma reflexão crítica sobre a atuação de arqueólogos enquanto cúmplices, sendo ...
Bruna Cigaran da Rocha +4 more
doaj +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
Journal of Digital Imaging, 2005 Acquiring, implementing, and maintaining a picture archiving and communication system (PACS) is an enduring and complex endeavor. A large-scale project such as this requires efficient and effective communication among a large number of stakeholders, sharing of complex documentation, recording ideas, experiences, and events such as meetings, and project
Pattanasak Mongkolwat +3 more
openaire +2 more sources
Advanced Science, EarlyView.A soft mechanoluminescent tactile sensor that converts force directly into light is presented, enabling imaging‐based, wiring‐free touch sensing. By integrating a flexible ML‐skin with CMOS readout, the system achieves high sensitivity, fast response, and high spatial resolution, while maintaining structural simplicity and energy efficiency, offering a
Yu Feng +11 more
wiley +1 more source
Análisis de escenarios de políticas para la gestión pública de la agricultura de regadío
Economía Agraria y Recursos Naturales, 2011 En este trabajo se presenta un enfoque metodológico para el análisis de presiones e impactos de la aplicación conjunta de diferentes escenarios de política agraria y de tarifación del agua de riego.
Laura Riesgo +1 more
doaj +1 more source
Adsorption of Forever Chemical Pollutants: The Physical Chemistry of PFAS Near Surfaces
Advanced Science, EarlyView.Current adsorption‐based remediation techniques for removing per‐ and polyfluoroalkyl substances (PFAS) from water are limited by knowledge gaps on PFAS behavior near solid surfaces. This review provides a state of the art on theoretical and experimental aspects of PFAS adsorption.
Nada Ben Amor +3 more
wiley +1 more source
Economía Agraria y Recursos Naturales, 2011 Las sucesivas reformas de la Política Agraria Común (PAC) han diseñado distintos instrumentos de protección para los productos continentales y para los productos mediterráneos en Europa, lo que ha originado diferentes estrategias de ajuste por parte de ...
Rosa María Gallardo-Cobos +2 more
doaj +1 more source