Results 1 to 10 of about 5,501 (96)

Comparing the impact of systemic pituitary adenylate-cyclase-activating polypeptide (PACAP) and calcitonin gene-related peptide (CGRP) on motion-induced nausea and balance behaviors in mice. [PDF]

PLoS ONE
Pituitary adenylate-cyclase-activating polypeptide (PACAP), particularly its dominant isoform PACAP-38, is implicated in migraine and represents a promising therapeutic target.
Shafaqat M Rahman, Abigail Dweh, Anne E Luebke   +2 more
doaj   +2 more sources

Pituitary adenylate cyclase-activating polypeptide mediates bacterial endotoxin-induced fever via an effect on cyclooxygenase-2 and inflammatory cytokines [PDF]

Scientific Reports
A role for pituitary adenylate cyclase-activating polypeptide (PACAP) signaling was suggested in bacterial lipopolysaccharide (LPS)-induced fever, but the underlying mechanisms of how PACAP contributes to the febrile response have remained unclarified ...
Jason Sparks, Nora Furedi, Kata Fekete, Margit Solymar, Krisztina Pohoczky, Agnes Kemeny, Dora Reglodi, Andras Garami, Eszter Pakai   +8 more
doaj   +2 more sources

Pituitary adenylate cyclase-activating polypeptide modulates circadian feeding and emotional behavior in mice independent of stress-induced hyperphagia [PDF]

Veterinary World
Background and Aim: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide widely implicated in stress responses, appetite regulation, and emotional behavior.
Ha Thi Thanh Nguyen, Thi Ngan Mai, Thi Thu Tra Vu, Thanh Trung Nguyen   +3 more
doaj   +2 more sources

Associations between PACAP levels and psychophysiological indicators of fear and arousal in adults with posttraumatic stress symptoms [PDF]

Journal of Mood and Anxiety Disorders
Posttraumatic stress disorder (PTSD) is associated with heightened fear responding and decreased fear regulation, as demonstrated with psychophysiological measures (e.g., autonomic function) and circulating biomarkers of stress, such as pituitary ...
Antonia V. Seligowski, Kevin J. Clancy, Eylül Akman, Michael Lewis, Victor May, Caitlin Ravichandran, Sydney A. Jobson, Daniel E. Bradford, Sayamwong E. Hammack, William A. Carlezon, Jr., Kerry J. Ressler, Scott L. Rauch, Isabelle M. Rosso   +12 more
doaj   +2 more sources

The PACAP/PAC1 Receptor System and Feeding

Brain Sciences, 2021
Pituitary adenylyl cyclase activating polypeptide (PACAP) belongs to the vasoactive intestinal polypeptide (VIP)/secretin/glucagon superfamily. PACAP is present in two forms (PACAP-38 and PACAP-27) and binds to three guanine-regulatory (G) protein ...
Keerthana Sureshkumar, Andrea Saenz, Syed M. Ahmad, Kabirullah Lutfy   +3 more
doaj   +1 more source

PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization

Frontiers in Endocrinology, 2021
Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano, Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Takanobu Nakazawa, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto   +12 more
doaj   +1 more source

The use of pituitary adenylate cyclase-activating polypeptide in the pre-maturation system improves in vitro developmental competence from small follicles of porcine oocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective We investigated how pituitary adenylate cyclase-activating polypeptide (PACAP) affects embryonic development during pre-in vitro maturation (pre-IVM) using porcine oocytes isolated from small follicles. Methods We divided the follicles into the
Kyu-Mi Park, Kyu-Jun Kim, Minghui Jin, Yongquan Han, Kyoung-Ha So, Sang-Hwan Hyun   +5 more
doaj   +1 more source

PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition

Molecular Metabolism, 2022
Objective: Pituitary adenylate cyclase-activating polypeptide (PACAP) was reported to attenuate hepatic lipid accumulation in overnutrition-related metabolic disorder, mediated by up-regulation of fas apoptosis inhibitory molecule (FAIM).
Wei Luo, Jiaxin Dai, Jianmin Liu, Yongmei Huang, Ziqiong Zheng, Pei Xu, Yi Ma   +6 more
doaj   +1 more source

Female reproductive functions of the neuropeptide PACAP

Frontiers in Endocrinology, 2022
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide originally isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a diverse spectrum of actions. Among other processes, PACAP has been shown to
Miklos Koppan, Zsuzsanna Nagy, Inez Bosnyak, Dora Reglodi   +3 more
doaj   +1 more source

Immunohistochemical Study on Glucagon-Like Peptide-1(GLP-1) and Pituitary Adenylate Cyclase Activating Peptide (PACAP) in the Small Intestine of Muscovy Duck during the Prehatching and Posthatching Periods

The Journal of Poultry Science, 2014
The distributions and frequencies of some endocrine cells in the small intestine of Muscovy duck during development were studied with immunohistochemical method using two types of antisera against Glucagon-like peptide-1(GLP-1) and Pituitary adenylate ...
Baoan Ding, Carla Lenzi, Andrea Pirone
doaj   +1 more source