Results 11 to 20 of about 5,551 (138)
Positive allosteric regulation of PAC1-R up-regulatesPAC1-R and its specific ligand PACAP
Acta Biochimica et Biophysica Sinica, 2022 PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide (PACAP), which mediates neuroprotective and nerve regenerative activities of PACAP.
Fan Guangchun +4 more
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PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
Alzheimer’s Research & Therapy, 2023 Background Autophagy is vital in the pathogenesis of neurodegeneration. Thus far, no studies have specifically investigated the relationship between pituitary adenylate cyclase-activating polypeptide (PACAP) and autophagy, particularly in the context of ...
Qing Wang +3 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: The endogenous neurotrophic peptides pituitary adenylate cyclase-activating polypeptides (PACAP-27/38) protect against stroke, but the molecular mechanism remains unknown.
Yuji Kaneko +3 more
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Frontiers in Endocrinology, 2020 PACAP was discovered 30 years ago in Dr. Akira Arimura's laboratory. In the past three decades since then, it has become evident that this peptide plays numerous crucial roles in mammalian organisms.
Katalin Köves +5 more
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Neurobiology of Disease, 2012 Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors (PAC1, VPAC) are present in sensory neurons and vascular smooth muscle.
Adrienn Markovics +14 more
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Protective Effects of PACAP in Peripheral Organs
Frontiers in Endocrinology, 2020 Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is also expressed in peripheral organs but its peripheral protective effects have
Denes Toth +13 more
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Frontiers in Psychiatry, 2022 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with isoforms consisting of either 27 or 38 amino acids. PACAP is encoded by the adenylate cyclase activating peptide gene, ADCYAP1, in humans and the highly conserved ...
Manessa Riser, Seth Davin Norrholm
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Role of PACAP in female fertility and reproduction at gonadal level - recent advances
Frontiers in Endocrinology, 2012 Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic neuropeptide, first isolated from hypothalamic extracts, but later shown in peripheral organs, such as endocrine glands, gastrointestinal system, cardiovascular system and ...
Dora eReglodi +4 more
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Frontiers in Endocrinology, 2022 The Hatschek’s pit in the cephalochordate amphioxus, an invertebrate deuterostome basal to chordates is suggested to be the functional homolog structure of the vertebrate adenohypophysis based on anatomy and expression of homologous neuroendocrine genes.
Jason S. W. On +7 more
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Frontiers in Behavioral Neuroscience, 2012 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide acting as a neurotransmitter, neuromodulator, or neurotrophic factor. PACAP is widely expressed throughout the brain and exerts its functions through the PACAP-specific receptor
Satoko eHattori +15 more
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