Results 21 to 30 of about 5,551 (138)

Pituitary Adenylate Cyclase Activating Polypeptide Has Inhibitory Effects on Melanoma Cell Proliferation and Migration In Vitro

Frontiers in Oncology, 2021
Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide which is distributed throughout the body. PACAP influences development of various tissues and exerts protective function during cellular stress and in some tumour ...
Tibor Hajdú, Patrik Kovács, Emese Zsigrai, Roland Takács, Judit Vágó, Sinyoung Cho, Sinyoung Cho, László Sasi-Szabó, Dániel Becsky, Aniko Keller-Pinter, Gabriella Emri, Kálmán Rácz, Dora Reglodi, Róza Zákány, Tamás Juhász   +14 more
doaj   +1 more source

Hormonal Regulation of Glucocorticoid Inactivation and Reactivation in αT3-1 and LβT2 Gonadotroph Cells

Biology, 2019
The regulation of reproductive function by glucocorticoids occurs at all levels of the hypothalamo-pituitary-gonadal axis. Within the pituitary, glucocorticoids have been shown to directly alter gene expression in gonadotrophs, indicating that these cell
Anthony E. Michael, Lisa M. Thurston, Robert C. Fowkes   +2 more
doaj   +1 more source

Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Treatment during Pre-maturation Increases the Maturation of Porcine Oocytes Derived from Small Follicles

Journal of Animal Reproduction and Biotechnology, 2018
Cellular cyclic adenosine-3’ 5’-monophosphate (cAMP) modulator is known as meiotic inhibitor and can delays spontaneous maturation in IVM experiment. Among many cAMP modulators, the role of Pituitary adenylate cyclase activating polypeptide (PACAP) on ...
Kyu-Mi Park, Kyoung-Ha So, Sang-Hwan Hyun   +2 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Hippocampal Synaptic Transmission and Plasticity: New Therapeutic Suggestions for Fragile X Syndrome

Frontiers in Cellular Neuroscience, 2019
Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates glutamatergic synaptic transmission and plasticity in the hippocampus, a brain area with a key role in learning and memory.
Lucia Ciranna, Lara Costa
doaj   +1 more source

Increased pituitary adenylate cyclase-activating peptide genes expression in the prefrontal cortex in schizophrenia in relation to suicide

Frontiers in Molecular Neuroscience, 2023
IntroductionPituitary adenylate cyclase-activating peptide (PACAP) is a stress-related neuropeptide that is produced in several brain areas. It acts by 3 receptors: PACAP type-1 (PAC1), vasoactive intestinal peptide (VIP) -1 and -2 (VPAC1 and 2). Data on
Zala Slabe, Zala Slabe, Rawien A. Balesar, Ronald W. H. Verwer, Gorazd Drevenšek, Dick F. Swaab, Dick F. Swaab   +6 more
doaj   +1 more source

Protective effects of PACAP in ischemia

The Journal of Headache and Pain, 2018
Pituitary adenylate cyclase activating polypeptide (PACAP) is an ubiquitous peptide involved, among others, in neurodevelopment, neuromodulation, neuroprotection, neurogenic inflammation and nociception. Presence of PACAP and its specific receptor, PAC1,
Dora Reglodi, Alexandra Vaczy, Eloísa Rubio-Beltran, Antoinette MaassenVanDenBrink   +3 more
doaj   +1 more source

Multimodal Role of PACAP in Glioblastoma [PDF]

Brain Sciences, 2021
Glioblastoma multiforme (GBM) is the deadliest form of brain tumors. To date, the GBM therapeutical approach consists of surgery, radiation-therapy and chemotherapy combined with molecules improving cancer responsiveness to treatments. In this review, we will present a brief overview of the GBM classification and pathogenesis, as well as the ...
D'amico A. G., Maugeri G., Vanella L., Pittala V., Reglodi D., D'agata V.   +5 more
openaire   +3 more sources

PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor

Frontiers in Cellular Neuroscience, 2019
Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine ...
Sara Hougaard Pedersen, Sara Hougaard Pedersen, Sanne Hage la Cour, Sanne Hage la Cour, Kirstine Calloe, Frank Hauser, Jes Olesen, Jes Olesen, Dan Arne Klaerke, Inger Jansen-Olesen, Inger Jansen-Olesen   +10 more
doaj   +1 more source

Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)

Frontiers in Neuroscience, 2020
Pituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide regulates neurotransmitter release, intestinal motility, metabolism, cell division ...
João C. R. Cardoso, Manuel G. Garcia, Deborah M. Power   +2 more
doaj   +1 more source

Pituitary adenylate cyclase-activating polypeptide plays a role in neuropsychiatric and substance use disorders: sex-specific perspective

Frontiers in Neuroscience
The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) plays a pivotal role in regulating stress, fear, and anxiety responses. Genetic and molecular studies investigating PACAP demonstrate sex-dimorphic characteristics, with females ...
Catherine E. Van Doorn, Mikala M. Zelows, Anel A. Jaramillo   +2 more
doaj   +1 more source