Results 31 to 40 of about 5,551 (138)
eLife, 2021 The neuropeptide PACAP, acting as a co-transmitter, increases neuronal excitability, which may enhance anxiety and arousal associated with threat conveyed by multiple sensory modalities. The distribution of neurons expressing PACAP and its receptor, PAC1,
Limei Zhang +6 more
doaj +1 more source
Pituitary adenylate cyclase activating peptide (PACAP) participates in adipogenesis by activating ERK signaling pathway. [PDF]
PLoS ONE, 2013 Pituitary adenylate cyclase activating peptide (PACAP) belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) family. Its action can be mediated by three different receptor subtypes: PAC1, which has exclusive affinity for PACAP, and VPAC1 ...
Tatjana Arsenijevic +6 more
doaj +1 more source
PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. [PDF]
PLoS ONE, 2015 Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts neurotrophic activities including modulation of synaptic plasticity and memory, hippocampal neurogenesis, and neuroprotection, most of which are shared with brain-derived neurotrophic ...
Katsuya Ogata +17 more
doaj +1 more source
Neurobiology of Disease, 2023 The mood disorders major depressive disorder (MDD) and bipolar disorder (BD) are highly prevalent worldwide. Women are more vulnerable to these psychopathologies than men. The bed nucleus of the stria terminalis (BNST), the amygdala, and the hypothalamus
Zala Slabe +6 more
doaj +1 more source
The Journal of Headache and Pain, 2018 Background Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and is involved in migraine pathophysiology.
Faisal Mohammad Amin +1 more
doaj +1 more source
Inhibition of retinal ganglion cell apoptosis: regulation of mitochondrial function by PACAP
Neural Regeneration Research, 2018 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an endogenous peptide with neuroprotective effects on retinal neurons, but the precise mechanism underlying these effects remains unknown.
Huan-Huan Cheng +4 more
doaj +1 more source
Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome. [PDF]
PLoS ONE, 2017 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an inhibitor of megakaryopoiesis and platelet function. Recently, PACAP deficiency was observed in children with nephrotic syndrome (NS), associated with increased platelet count and ...
Benedicte Eneman +7 more
doaj +1 more source
Neurobiology of Disease, 2013 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic peptide with autocrine neuroprotective and paracrine anti-inflammatory properties in various models of acute neuronal damage and neurodegenerative diseases.
Cornelia Ringer +5 more
doaj +1 more source
PACAP upsets stomach theory [PDF]
Journal of Clinical Investigation, 1999 Gastric acid secretion plays an essential role in the pathogenesis of peptic ulcer disease and gastroesophageal reflux disease. These chronic recurring diseases affect approximately 20–40% of the adult population (1) and result in significant morbidity, lost work, and billions of health care dollars.
openaire +3 more sources
Biomolecules, 2022 We have previously shown that spinal pituitary adenylate cyclase-activating polypeptide (PACAP)/PACAP type 1 (PAC1) receptor signaling triggered long-lasting nociceptive behaviors through astroglial activation in mice.
Yuki Kambe +6 more
doaj +1 more source