Results 41 to 50 of about 5,551 (138)

Pituitary Adenylate Cyclase-Activating Peptide (PACAP)-Glutamate Co-transmission Drives Circadian Phase-Advancing Responses to Intrinsically Photosensitive Retinal Ganglion Cell Projections by Suprachiasmatic Nucleus

Frontiers in Neuroscience, 2019
Results from a variety of sources indicate a role for pituitary adenylate cyclase-activating polypeptide (PACAP) in light/glutamate-induced phase resetting of the circadian clock mediated by the retinohypothalamic tract (RHT). Attempts to block or remove
Peder T. Lindberg, Jennifer W. Mitchell, Penny W. Burgoon, Christian Beaulé, Eberhard Weihe, Martin K.-H. Schäfer, Lee E. Eiden, Sunny Z. Jiang, Martha U. Gillette, Martha U. Gillette   +9 more
doaj   +1 more source

New function of PACAP on hematopoiesis through PACAP specific receptor (PAC1R)

Folia Pharmacologica Japonica, 2018
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide, and exists diverse physiological functions such as a cell protection, anti-inflammation, and neuronal proliferation and differentiation. There are many evidences that PACAP contributes to the neuronal developmental processes during embryonic periods and after the birth, and ...
Hirokazu, Ohtaki, Kazumichi, Yagura, Zhifang, Xu   +2 more
openaire   +3 more sources

PACAP inhibits β-cell mass expansion in a mouse model of type II diabetes: persistent suppressive effects on islet density

Frontiers in Endocrinology, 2013
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent insulinotropic G-protein-coupled receptor ligand, for which morphoregulative roles in pancreatic islets have recently been suggested.
Hiroaki eInoue, Norihito eShintani, Yusuke eSakurai, Yusuke eSakurai, Shintaro eHigashi, Shintaro eHigashi, Atsuko eHayata-Takano, Atsuko eHayata-Takano, Akemichi eBaba, Akemichi eBaba, Hitoshi eHashimoto, Hitoshi eHashimoto   +11 more
doaj   +1 more source

Pituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target. [PDF]

PLoS ONE, 2014
Pituitary adenylate cyclase activating polypeptide (PACAP) is an important neurotrophic factor influencing differentiation of neuronal elements and exerting protecting role during traumatic injuries or inflammatory processes of the central nervous system.
Tamás Juhász, Csaba Matta, Éva Katona, Csilla Somogyi, Roland Takács, Pál Gergely, László Csernoch, Gyorgy Panyi, Gábor Tóth, Dóra Reglődi, Andrea Tamás, Róza Zákány   +11 more
doaj   +1 more source

VIP and PACAP

British Journal of Pharmacology, 2009
Vasoactive intestinal polypeptide (VIP) is derived from a 170 amino acid precursor which in addition is processed to preproVIP 22-79, PHI, preproVIP 111-122 and preproVIP 156-170. All preproVIP-derived peptides have been shown in normal tissue and VIP-producing cell lines and elevated quantities occur in plasma and tumour tissues from patients with VIP-
openaire   +5 more sources

Immunomodulatory Effects of the Neuropeptide Pituitary Adenylate Cyclase-Activating Polypeptide in Acute Toxoplasmosis

Frontiers in Cellular and Infection Microbiology, 2019
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is an endogenous neuropeptide with distinct functions including the regulation of inflammatory processes.
Caio Andreeta Figueiredo, Henning Peter Düsedau, Johannes Steffen, Nishith Gupta, Miklos Pal Dunay, Gabor K. Toth, Dora Reglodi, Markus M. Heimesaat, Ildiko Rita Dunay, Ildiko Rita Dunay   +9 more
doaj   +1 more source

Immunohistochemical Study on the Innervation of the Chicken Pancreas by Pituitary Adenylate Cyclase-Activating Polypeptides (PACAPs)-Containing Nerves

The Journal of Poultry Science, 2009
Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of secretin/glucagon/VIP family, has a potent action on the pancreatic secretion in mammals.
Kohzy Hiramatsu, Asa Yamasaki
doaj   +1 more source

Immunomodulatory effects of PACAP sequence modifications in juvenile white shrimp Litopenaeus vannamei

Comparative Immunology Reports
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved multifunctional neuropeptide belonging to the secretin/glucagon/vasoactive intestinal peptide superfamily.
Jesús Luis Betancourt, Tania Rodríguez-Ramos, Laura Rivera, Yamila Carpio, Mario Pablo Estrada, Laida Ramos, Brian Dixon   +6 more
doaj   +1 more source

Pituitary cyclase‐activating polypeptide targeted treatments for the treatment of primary headache disorders

Annals of Clinical and Translational Neurology
Objective Migraine is a complex and disabling neurological disorder. Recent years have witnessed the development and emergence of novel treatments for the condition, namely those targeting calcitonin gene‐related peptide (CGRP).
Nazia Karsan, Lars Edvinsson, Laszlo Vecsei, Peter J Goadsby   +3 more
doaj   +1 more source

VPAC1 receptors play a dominant role in PACAP-induced vasorelaxation in female mice.

PLoS ONE, 2019
BACKGROUND:PACAP and VIP are closely related neuropeptides with wide distribution and potent effect in the vasculature. We previously reported vasomotor activity in peripheral vasculature of male wild type (WT) and PACAP-deficient (KO) mice.
Ivan Ivic, Marta Balasko, Balazs D Fulop, Hitoshi Hashimoto, Gabor Toth, Andrea Tamas, Tamas Juhasz, Akos Koller, Dora Reglodi, Margit Solymár   +9 more
doaj   +1 more source