Results 101 to 110 of about 35,720 (287)
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
POLÍTICA DAS UPPS E ESPAÇOS ORGANIZACIONAIS PRECÁRIOS: UMA ANÁLISE DE DISCURSO [PDF]
RAE: Revista de Administração de Empresas, 2013 The present work aims to identify the hidden goals and power relationships existing in the UPP Policy, disclosing the domination to which is subjected the population from precarious and fragile organizational spaces, such as slums, especially through the
Daniel da Silva Lacerda, Vanessa Brulon
doaj
Why Is Liberal Peace-building So Difficult? Some Lessons from Central America [PDF]
The termination of war is mostly seen as a basis not just for recovery but for a fundamental transformation or change in development paths towards peace, stability and development.
Sabine Kurtenbach
core
Advanced Science, EarlyView.A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Advanced Science, EarlyView.The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob +12 more
wiley +1 more source
A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data
Advanced Science, EarlyView.SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang +5 more
wiley +1 more source
Experiences of person-centered care for sundown syndrome among nurses and nurse aides in dementia special care units: a qualitative study. [PDF]
BMC Nurs, 2023 Huang SF, Wang BY, Liao JY.
europepmc +1 more source
scope of Dharma w.s.r. to ritual dieties (karma kanda) in AYurveda [PDF]
, 2015 Ayurveda is science of living being. Aim of Ayurveda is mantainance of healthy life and pacification of diseases of diseased ones. Dharma, artha, kama and moksha these four are together called chaturvidha purushartha which is achieved by arogya (health ...
Upadhyay, Dr Devanand
core