Results 41 to 50 of about 35,720 (287)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Labour mobility and diaspora: An overview of Solomon Islands’ historical regulatory experience, 1850s-2013 [PDF]

, 2014
With less than 4,500 of its population of around 600,000 living overseas in 2013, the Solomon Islands ranks 138th in the world for diaspora formation.
Bedford, Richard, Craig, David, Friesen, Ward, Gegeo, David, Miller, Rebecca, Rodi, Patricia   +5 more
core   +1 more source

Periodization of Development of Ethnic Relations of Western Ukraine and Poland (1918–1939) [PDF]

, 2018
The article makes an attempt to investigate the peculiarities and determine the regularities of cooperation between the Ukrainian and Polish states during the time of the Second Rzeczpospolita, to recreate the overall picture of events and their ...
Bilan, S. (Serhii), Pylypenko, L. (Lilia)   +1 more
core   +2 more sources

Physician Referral Patterns to Physical Therapists for Managing Knee Osteoarthritis: A Retrospective Analysis of Electronic Health Records From an Integrated Health System

Arthritis Care &Research, EarlyView.
Objective This study aims to describe the frequency and timing of physician referrals to physical therapists (PTs) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja, Joel M. Stevans, Gustavo J. Almeida, Clair Smith, Janet K. Freburger   +4 more
wiley   +1 more source

La mediación femenina como forma de acción política

E-Spania, 2015
Dans cet article, nous étudions les pratiques de médiation auxquelles des femmes liées aux milieux monarchiques eurent recours lors de conflits politiques, dans les royaumes ibériques de la période Trastamare.
Ángela Muñoz Fernández
doaj   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Una reina en la retaguardia: las intervenciones pacificadoras de Isabel la Católica en la guerra de sucesión

E-Spania, 2015
Cet article examine certaines des actions de pacificatrices réalisées par la reine Isabelle au cours de la guerre de succession à la Couronne de Castille dans les premières années du dernier quart du XVe siècle.
María del Pilar Rábade Obradó
doaj   +1 more source

Testing a Personalized Approach to Chronic Low Back Pain: A Randomized Controlled Trial in Older Veterans

Arthritis Care &Research, EarlyView.
Objective We aimed to test the efficacy of personalized treatment of older veterans with chronic low back pain (CLBP) delivered by Aging Back Clinics (ABCs) as compared with usual care (UC). Methods Two hundred ninety‐nine veterans aged 65 to 89 with CLBP from three Veterans Affairs (VA) medical centers underwent baseline testing, randomization to ABC ...
Debra K. Weiner, Angela Gentili, Meika A. Fang, Edward Garay, Laura Lawson, Lenore Joseph, Cathy C. Lee, Michelle I. Rossi, Beverly Thorn, Subashan Perera   +9 more
wiley   +1 more source

Conflict, Environment and Transition: Colombia, Ecology and Tourism after Demobilisation

International Journal for Crime, Justice and Social Democracy, 2019
In 2016, Colombia’s left-wing guerrilla FARC-EP (Fuerzas Armadas Revolucionarias de Colombia—Ejército del Pueblo) began demobilisation. While demobilisation and the ensuing peace accords brought renewed hope that the country could imagine different ...
Bill McClanahan, Tatiana Sanchez Parra, Avi Brisman   +2 more
doaj   +1 more source