Results 151 to 160 of about 1,916,863 (341)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Applications of heat pipes to cool PWBS and hybrid microcircuits [PDF]
Some of the advanced thermal management techniques used to reduce operating junction temperature under extreme environmental temperature conditions are discussed.
Sekhon, K. S.
core +1 more source
Lightweight magnesium-lithium alloys show promise [PDF]
, 1964 Evaluation tests show that magnesium-lithium alloys are lighter and more ductile than other magnesium alloys.
Adams, W. T., Cataldo, C. E.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Plain Tobacco Packaging: A Systematic Review [PDF]
, 2012 (From the Executive Summary): This systematic review outlines findings from 37 studies that provide evidence of the impacts of plain tobacco packaging.
Angus, Kathryn +9 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
تاثیر مولفه های مدیریت منابع انسانی برعملکرد شرکت های کارتن سازی [PDF]
علوم و فنون بسته بندییکی از مهمترین چالشهای موجود در مسیر رشد و توسعه صنایع کارتنسازی در ایران توانایی ایجاد ارتباط و هماهنگی میان راهبرد منابع انسانی با اهداف و راهبردهای استراتژیک هر سازمان میباشد.
شادمان پورموسی +2 more
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
روندهاوچالشهای فومهای بر پایه نشاسته و سلولز بهعنوان جایگزینهای رقابتی پلی استایرن منبسطشده [PDF]
علوم و فنون بسته بندیپلی استایرن منبسطشده یک پلیمر ارزان است و بهطور گستردهای در دسترس است و در فومهای بستهبندی بکار میرود. بااینحال فومهای مبتنی بر پلی استایرن منبسطشده باعث ایجاد مشکلات زیستمحیطی میشوند زیرا تجزیهناپذیر بوده و بازیافت کمی دارند. بنابراین، تولید
نرجس جنتی ها +2 more
doaj