Results 71 to 80 of about 111,140 (282)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Improving Live Streaming QoE Through HLS Parameter Tuning and Load Balancing to Mitigate Packet Loss

Kurdistan Journal of Applied Research
Live video streaming denotes a video distribution service that concurrently captures and transmits media material to all consumers in real time. In recent years, most of the internet has been used for video streaming, as platforms have transformed ...
Bzav Shorsh Sabir , Aree Ali Mohammad
doaj   +1 more source

Rateless Codes with Progressive Recovery for Layered Multimedia Delivery

, 2012
This paper proposes a novel approach, based on unequal error protection, to enhance rateless codes with progressive recovery for layered multimedia delivery. With a parallel encoding structure, the proposed Progressive Rateless codes (PRC) assign unequal
Chen, Zhao, Lu, Jianhua, Xu, Mai, Yin, Liuguo   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fuzzy Clustering with Multi-Constraint QoS Service Routing in Wireless Sensor Networks

Journal of Telecommunications and Information Technology, 2019
This paper presents a fuzzy logic-based, service differentiated, QoS aware routing protocol (FMSR) offering multipath routing for WSNs, with the purpose of providing a service differentiated path meant for communication between nodes, based on actual ...
Jayashree V. Agarkhed, Vijayalaxmi Kadrolli, Siddarama R. Patil   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Compressive sensing based data gathering algorithm over unreliable links in WSN

Tongxin xuebao, 2016
To solve the problem that the ubiquitous unreliable links in the WSN influence the performance of the compressive sensing (CS) based data gathering,first the relationship between the reconstruction SNR of CS-based data gathering algorithm and the bit ...
Ce ZHANG, Xia ZHANG, Ou LI, Guan-lin MEI, Zhe HAN, Da-long ZHANG, Guang-yi LIU   +6 more
doaj   +2 more sources

Reliable routing scheme for indoor sensor networks [PDF]

, 2010
Indoor Wireless sensor networks require a highly dynamic, adaptive routing scheme to deal with the high rate of topology changes due to fading of indoor wireless channels.
Cole, P., Daabaj, K., Dixon, M.W., Koziniec, T.   +3 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Resource Allocation to Massive Internet of Things in LoRaWANs

Sensors, 2020
A long-range wide area network (LoRaWAN) adapts the ALOHA network concept for channel access, resulting in packet collisions caused by intra- and inter-spreading factor (SF) interference. This leads to a high packet loss ratio.
Arshad Farhad, Dae-Ho Kim, Jae-Young Pyun   +2 more
doaj   +1 more source