Results 131 to 140 of about 310,664 (317)

Sphere-Packing Modulated Space-Time Coding Using Non-Binary LDPC-Coded Iterative-Detection

, 2008
A recently proposed Space-Time Block Coding (STBC) signal construction method that combines orthogonal design with sphere packing, referred to here as (STBC-SP), has shown useful performance improvements over Alamouti’s conventional orthogonal design. In
Alamri, Osamah, F. Guo, Ng, Soon, S. X. Ng, O. Alamri, S. Zummo, L. Hanzo, Guo, Feng, Zummo, S, Hanzo, Lajos   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Percolation connectivity in deposits obtained usingcompetitive random sequential adsorption of binarydisk mixtures

Condensed Matter Physics
Connectedness percolation phenomena in the two-dimensional (2D) packing of binary mixtures of disks with different diameters were studied numerically. The packings were produced using random sequential adsorption (RSA) model with simultaneous deposition
N. I. Lebovka, M. R. Petryk, N. V. Vygornitskii   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Probabilistic analysis of algorithms for dual bin packing problems

In the dual bin packing problem, the objective is to assign items of given size to the largest possible number of bins, subject to the constraint that the total size of the items assigned to any bin is at least equal to 1.
Rinnooy Kan, A.H.G., Frenk, J.B.G., Csirik, J., Galambos, G.   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A simple proof of Liang's lower bound for on-line bin packing and the extension to the parametric case

In this note we present a simplified proof of a lower bound for on-line bin packing. This proof also covers the well-known result given by Liang in Inform. Process Lett. 10 (1980) 76–79.
Frenk, J.B.G., Galambos, G.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Two-dimensional rectangle packing: on-line methods and results

The first algorithms for the on-line two-dimensional rectangle packing problem were introduced by Coppersmith and Raghavan. They showed that for a family of heuristics 13/4 is an upper bound for the asymptotic worst-case ratios.
Labbé, M., Frenk, J.B.G., Csirik, J.
core