Results 21 to 30 of about 186,890 (225)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Injective coloring of product graphs [PDF]

, 2023
The problem of injective coloring in graphs can be revisited through two different approaches: coloring the two-step graphs and vertex partitioning of graphs into open packing sets, each of which is equivalent to the injective coloring problem itself ...
Samadi, Babak, González Yero, Ismael, Yero, Ismael G., Soltankhah, Nasrin   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Constraint-aware deep Q-network with greedy fallback for large-scale multi-campus university examination scheduling

Array
University examination timetabling is NP-hard and is usually studied under two assumptions that fail here: fixed time slots and one exam per room. Exams last 60, 120, or 180 min, rooms host several back-to-back within a working day, and about half the ...
Mustafa Kaya
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A Quantum-Memetic Hybrid Framework for Combinatorial Optimization: Synergistic Integration of Superposition-Based Exploration with Adaptive Exploitation

AI
The effective resolution of non-deterministic polynomial time hard (NP-hard) combinatorial optimization problems requires a delicate balance between global exploration and local exploitation.
Raza Hasan, Vishal Dattana, Salman Mahmood   +2 more
doaj   +1 more source

Performance characteristics of a new structured packing [PDF]

, 2010
A new structured packing using carbon fibres, called Sepcarb® 4D, is presented. This packing has several attractive properties, such as high voidage (ε=94%) and high effective area (a=420 m2 m−3).
Abbé, François, Dumont, Charles, François Abbé, Meyer, Michel, Jean-Pierre Maumus, David Rouzineau, Charles Dumont, Prevost, Michel, Rouzineau, David, Bessou, Vincent, Michel Meyer, Michel Prévost, Vincent Bessou, Maumus, Jean-Pierre   +13 more
core   +1 more source