Results 91 to 100 of about 149,239 (310)
A Preview of a Construction of a Crystal Lattice Based on Intermolecular Interactions
Crystals, 2019 A general procedure of crystal packing reconstruction using a certain number of intermolecular interactions is introduced and demonstrated on the crystal structure of l-histidine·HCl·H2O.
Vladimír Hejtmánek +2 more
doaj +1 more source
Measures and the Law of the Iterated Logarithm
, 2009 Let m be a unidimensional measure with dimension d. A natural question is to ask if the measure m is comparable with the Hausdorff measure (or the packing measure) in dimension d.
Bhouri, Imen, Heurteaux, Yanick
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Packing and Cutting Stone Blocks Based on the Nonlinear Programming of Tree Cases
ComputationTypically, dimension stones, commonly called stone blocks, are cut into multiple small cuboid stones so that multiple sculptures can be produced. To use the stone block as efficiently as possible, it is essential to pack these small cuboids in each stone
Taeyong Kim
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
On symplectic packing problems in higher dimensions
Mathematische AnnalenAbstract Let $$B^{2n}(R)$$ denote the closed 2n-dimensional symplectic ball of area R, and let $$\Sigma _g(L)$$ be a closed symplectic surface of genus g and area L. We prove that there is a symplectic embedding $$\bigsqcup \nolimits _{i=1}^k B^4(R_i) \times \Sigma _g (L) \
Kyler Siegel, Yuan Yao
openaire +3 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source