Results 91 to 100 of about 331,306 (335)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
A new perspective on the analysis of helix-helix packing preferences in globular proteins
, 2003 For many years it had been believed that steric compatibility of helix interfaces could be the source of the observed preference for particular angles between neighbouring helices as emerging from statistical analysis of protein databanks.
Seno, F., Trovato, A.
core +1 more source
ON CANTOR SETS AND PACKING MEASURES
Bulletin of the Korean Mathematical Society, 2015 For every doubling gauge g, we prove that there is a Cantor set of positive finite -measure, -measure, and -premeasure. Also, we show that every compact metric space of infinite -premeasure has a compact countable subset of infinite -premeasure. In addition, we obtain a class of uniform Cantor sets and prove that, for every set E in this class, there ...
CHUN WEI, SHENG-YOU WEN
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Packing ellipsoids with overlap
, 2012 The problem of packing ellipsoids of different sizes and shapes into an ellipsoidal container so as to minimize a measure of overlap between ellipsoids is considered. A bilevel optimization formulation is given, together with an algorithm for the general
Uhler, Caroline, Wright, Stephen J.
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Shear modulus and Dilatancy Softening in Granular Packings above Jamming
, 2014 We investigate experimentally the mechanical response of a monolayer of bi-disperse frictional grains to an inhomogeneous shear perturbation across the jamming transition.
Coulais, Corentin +2 more
core +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Packed Bed Performance Analytics Based on Gamma Scans
Chemical Engineering Transactions, 2018 Refinery and chemical plant operations depend heavily on distillation and separation towers. Tower gamma scanning is well established in the process industries as a qualitative tool to help troubleshoot towers. Advancements in data analysis have led to a
Scott Vidrine +2 more
doaj +1 more source
Thermophysical properties of near-Earth asteroid (341843) 2008 EV5 from WISE data
, 2013 Aims. To derive the thermal inertia of 2008 EV$_5$, the baseline target for the Marco Polo-R mission proposal, and infer information about the size of the particles on its surface. Methods.
Alí-Lagoa, V. +5 more
core +1 more source