Results 111 to 120 of about 7,672,439 (332)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
THE EXACT PACKING MEASURE OF LEVY TREES
, 2010 33 pages.We study fine properties of Lévy trees that are random compact metric spaces introduced by Le Gall and Le Jan in 1998 as the genealogy of continuous state branching processes.
Duquesne, Thomas
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The exact packing measure of Lévy trees
, 2010 33 pages.We study fine properties of Lévy trees that are random compact metric spaces introduced by Le Gall and Le Jan in 1998 as the genealogy of continuous state branching processes.
Duquesne, Thomas
core
Asymptotic order of quantization for Cantor distributions in terms of Euler characteristic, Hausdorff and Packing measure [PDF]
, 2008 For homogeneous one-dimensional Cantor sets, which are not necessarily self-similar, we show under some restrictions that the Euler exponent equals the quantization dimension of the uniform distribution on these Cantor sets.
Kreitmeier, Wolfgang
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Communications PhysicsUnlike crystalline solids, liquids lack long-range order, resulting in diffusive shear fluctuations rather than propagating waves. Simulations predict that liquids exhibit a k-gap in wave-vector space, where solid-like transverse waves reappear above ...
Cunyuan Jiang +4 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
BoreasThis study examines the distribution and morphology of lakes under the Laurentide Ice Sheet (LIS) to investigate relationships with ice flow velocity, bedrock and basal thermal regime.
Sarah M. Principato, Carissa M. Mobley
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source