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Annals of Oncology, 1995 Paclitaxel (Taxol) is a new antineoplastic agent derived from the bark of the western yew, Taxus brevifolia, with important activity against several tumors such as ovarian cancer, breast cancer, lung cancer and head and neck cancer. Because it promotes microtubule assembly, neuropathy occurs as one of its toxic side effects. Our purpose was to evaluate
T.J. Postma +4 more
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Mining natural products related to paclitaxel reveals the possible biosynthetic pathway of paclitaxel [PDF]
BIO Web of Conferences, 2023 Paclitaxel is a widely used anti-tumor drug. Currently, paclitaxel can only be extracted from plants or synthesized by chemical semi-synthesis, which cause environmental damage and cannot meet the growing demand.
Sun Juncong +5 more
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Way to efficient microbial paclitaxel mass production
Synthetic and Systems Biotechnology, 2023 The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain ...
Chenyue Li +4 more
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Albumin-Bound Paclitaxel: Worthy of Further Study in Sarcomas
Frontiers in Oncology, 2022 Taxanes (paclitaxel and docetaxel) play an important role in the treatment of advanced sarcomas. Albumin-bound paclitaxel (nab-paclitaxel) is a new kind of taxane and has many advantages compared with paclitaxel and docetaxel. Nab-paclitaxel is currently
Zhichao Tian, Weitao Yao
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BMC Cancer, 2021 Background Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers.
Celina Amaya +5 more
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Frontiers in Oncology, 2022 ObjectiveWe conducted a phase 2 trial to compare the safety and efficacy of intravenous paclitaxel or intraperitoneal paclitaxel plus mFOLFOX6 vs. mFOLFOX6 in untreated advanced gastric cancer.MethodsParticipants with untreated advanced gastric cancer ...
Shen Zhao +16 more
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Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
Oxidative Medicine and Cellular Longevity, 2021 Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt.
Javad Sharifi‐Rad +23 more
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The Taxus genome provides insights into paclitaxel biosynthesis
Nature Plants, 2021 The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome
Xingyao Xiong +18 more
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Pathomechanisms of Paclitaxel-Induced Peripheral Neuropathy
Toxics, 2021 Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces neuropathy in up to 97% of all gynecological and urological cancer patients.
Ines Klein, H. Lehmann
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Biomedicines, 2023 Taxanes (paclitaxel and docetaxel) are one of the most useful classes of anticancer drugs. Taxanes are highly hydrophobic; therefore, these drugs must be dissolved in organic solvents (polysorbate or Cremophor EL), which contribute to their toxicities ...
Md Sazzad Hassan +3 more
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