Results 21 to 30 of about 357,544 (339)

Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous Non-Small-Cell Lung Cancer (IMpower131): Results From a Randomized Phase III Trial.

Journal of Thoracic Oncology, 2020
INTRODUCTION Cytotoxic agents have immunomodulatory effects, providing rationale for combining atezolizumab (anti-programmed death-ligand 1 [PD-L1]) with chemotherapy.
R. Jotte, F. Cappuzzo, I. Vynnychenko, D. Stroyakovskiy, D. Rodríguez-Abreu, M. Hussein, R. Soo, H. Conter, T. Kozuki, Kuan-Chieh Huang, Vilma Graupner, Shawn W. Sun, T. Hoang, H. Jessop, M. McCleland, M. Ballinger, A. Sandler, M. Socinski   +17 more
semanticscholar   +1 more source

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells [PDF]

, 2018
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits.
Flores, M. Luz, Gasca Bellido, Jessica María, Japón Rodríguez, Miguel Ángel, Jiménez Guerrero, Rocío, Medina, Rafael, Pérez Valderrama, Begoña, Romero Portillo, Francisco, Tortolero García, María Dolores   +7 more
core   +1 more source

Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin–Bound Paclitaxel in Rats

Journal of Pharmacological Sciences, 2011
.: Nanoparticle albumin–bound paclitaxel (nab-paclitaxel) is delivered to tumors and increases antitumor activity compared with solvent-based paclitaxel.
Yuji Yamashita, Nobuaki Egashira, Ken Masuguchi, Soichiro Ushio, Takehiro Kawashiri, Ryozo Oishi   +5 more
doaj   +1 more source

Nab-Paclitaxel in the Treatment of Gastrointestinal Cancers—Improvements in Clinical Efficacy and Safety

Biomedicines, 2023
Taxanes (paclitaxel and docetaxel) are one of the most useful classes of anticancer drugs. Taxanes are highly hydrophobic; therefore, these drugs must be dissolved in organic solvents (polysorbate or Cremophor EL), which contribute to their toxicities ...
Md Sazzad Hassan, Niranjan Awasthi, Saisantosh Ponna, Urs von Holzen   +3 more
doaj   +1 more source

Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy [PDF]

, 2013
Confocal Raman microscopy, a non-invasive, label-free, and high spatial resolution imaging technique is employed to trace the anticancer drug paclitaxel in living Michigan Cancer Foundation-7 (MCF-7) cells. The Raman images were treated by K-mean cluster
A.-G. Vegh, C. Gergely, C. Larroque, F. J. G. Cuisinier, H. Salehi, J.-C. Durand, Kuh H. J., L. Derely, Levenson A. S., M.-A. Fauroux   +9 more
core   +4 more sources

Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy

Oxidative Medicine and Cellular Longevity, 2021
Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt.
Javad Sharifi‐Rad, Cristina Quispe, J. Patra, Y. Singh, M. K. Panda, Gitishree Das, C. Adetunji, O. Michael, O. Sytar, L. Polito, J. Živković, N. Cruz-Martins, Marta Klimek-Szczykutowicz, H. Ekiert, M. Choudhary, S. A. Ayatollahi, B. Tynybekov, F. Kobarfard, A. Muntean, I. Grozea, S. Daştan, Monica Butnariu, A. Szopa, D. Calina   +23 more
semanticscholar   +1 more source

Randomized phase II study investigating pazopanib versus weekly paclitaxel in relapsed or progressive urothelial cancer [PDF]

, 2017
Purpose: Two previous single-arm trials have drawn conflicting conclusions regarding the activity of pazopanib in urothelial cancers after failure of platinum-based chemotherapy.
Alexander, Laura, Bahl, Amit, Birtle, Alison, Chakraborti, Prabir, Crabb, Simon J., Dixon-Hughes, Judith, Huddart, Robert A., Hussain, Syed A., Jagdev, Satinder, Jones, Robert J., Kelly, Caroline, Morris, Anna, Paul, James, Powles, Thomas, Protheroe, Andrew S., Stobo, Jon, Stockdale, Andrew, Sundar, Santhanam   +17 more
core   +2 more sources

Treating cisplatin-resistant cancer: a systematic analysis of oxaliplatin or paclitaxel salvage chemotherapy [PDF]

, 2009
Objective: To examine the pre-clinical and clinical evidence for the use of oxaliplatin or paclitaxel salvage chemotherapy in patients with cisplatin-resistant cancer.
B Stordal, B Stordal, BK Stordal, H Kawai, H Kuroda, M Markman, S Henness, V Dieras   +7 more
core   +2 more sources

Atezolizumab and Nab‐Paclitaxel in Advanced Triple‐Negative Breast Cancer

New England Journal of Medicine, 2018
Background Unresectable locally advanced or metastatic triple‐negative (hormone‐receptor–negative and human epidermal growth factor receptor 2 [HER2]–negative) breast cancer is an aggressive disease with poor outcomes.
P. Schmid, S. Adams, H. Rugo, A. Schneeweiss, C. Barrios, H. Iwata, V. Diéras, R. Hegg, S. Im, G. Shaw Wright, V. Henschel, L. Molinero, S. Chui, R. Funke, A. Husain, E. Winer, S. Loi, L. Emens   +17 more
semanticscholar   +1 more source

The Taxus genome provides insights into paclitaxel biosynthesis

Nature Plants, 2021
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome
Xingyao Xiong, Junbo Gou, Qinggang Liao, Yanlin Li, Qian Zhou, Guiqi Bi, Chong Li, Ran Du, Xiao-Tong Wang, T. Sun, Lvjun Guo, Haifei Liang, Pengjun Lu, Yaoyao Wu, Zhonghua Zhang, D. Ro, Y. Shang, Sanwen Huang, Jianbin Yan   +18 more
semanticscholar   +1 more source