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Pharmacogenomics of Paclitaxel [PDF]

Pharmacogenomics, 2010
The microtubule-stabilizing drug paclitaxel is a cytotoxic agent widely used for the treatment of a variety of tumor types. Since its introduction to the clinic, modifications to the administration schedule and treatments for hypersensitivity reactions and neutropenia have significantly improved paclitaxel therapy.
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Paclitaxel Induces Acute Pain via Directly Activating Toll like Receptor 4

Molecular Pain, 2015
Paclitaxel, a powerful anti-neoplastic drug, often causes pathological pain, which significantly reduces the quality of life in patients. Paclitaxel-induced pain includes pain that occurs immediately after paclitaxel treatment (paclitaxel-associated ...
Xisheng Yan, Dylan W Maixner, Ruchi Yadav, Mei Gao, Pei Li, Michael G Bartlett, Han-Rong Weng   +6 more
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CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2

Frontiers in Pharmacology, 2021
Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important role.
Yaqing Zhang, Hongyun Gan, Fei Zhao, Xiaomei Ma, Xiaofeng Xie, Rui Huang, Jin Zhao   +6 more
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Effect of paclitaxel and resveratrol on New Zealand rabbit semen

Asian Pacific Journal of Reproduction, 2018
Objective: To examine the effects of paclitaxel and resveratrol on rabbit semen. Methods: This study consisted of four groups: control group (40 mL saline), paclitaxel group (5 mg/kg paclitaxel), resveratrol group (4 mg/kg resveratrol) and paclitaxel ...
Caner Ozturk, Mehmet Bozkurt Ataman
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Paclitaxel Increases High Voltage–Dependent Calcium Channel Current in Dorsal Root Ganglion Neurons of the Rat

Journal of Pharmacological Sciences, 2012
Peripheral neuropathic pain is a serious side effect of paclitaxel treatment. However, the mechanism of this paclitaxel-induced neuropathic pain is unknown. In this study, we investigated the effects of paclitaxel on the voltage-dependent calcium channel
Kazuyoshi Kawakami, Terumasa Chiba, Nobuyuki Katagiri, Maya Saduka, Kenji Abe, Iku Utsunomiya, Toshihiro Hama, Kyoji Taguchi   +7 more
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The battle of “nano” paclitaxel

Advanced Drug Delivery Reviews, 2017
Paclitaxel (PTX) is one of the three most widely used chemotherapeutic agents, together with doxorubicin and cisplatin, and is first or second line treatment for several types of cancers. In 2000, Taxol, the conventional formulation of PTX, became the best-selling cancer drug of all time with annual sales of 1.6 billion.
Sofias, Alexandros Marios, Dunne, Michael, Storm, Gert, Allen, Christine   +3 more
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Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction

Tumor Biology, 2017
Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a ...
Yimin Lu, Jun Wang, Lei Liu, Lequn Yu, Nian Zhao, Xingju Zhou, Xudong Lu   +6 more
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Adverse event profiles of solvent-based and nanoparticle albumin-bound paclitaxel formulations using the Food and Drug Administration Adverse Event Reporting System

SAGE Open Medicine, 2019
Objectives: Paclitaxel is a highly effective antitumor agent with notable adverse events, including hypersensitivity reactions, peripheral neuropathy, arthralgia, myalgias, and neutropenia.
Misa Naganuma, Kohei Tahara, Shiori Hasegawa, Akiho Fukuda, Sayaka Sasaoka, Haruna Hatahira, Yumi Motooka, Satoshi Nakao, Ririka Mukai, Kouseki Hirade, Tomoaki Yoshimura, Takeshi Kato, Hirofumi Takeuchi, Mitsuhiro Nakamura   +13 more
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Rikkunshito prevents paclitaxel-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice.

PLoS ONE, 2017
Peripheral neuropathy is the major side effect caused by paclitaxel, a microtubule-binding antineoplastic drug. Paclitaxel-induced peripheral neuropathy causes a long-term negative impact on the patient's quality of life.
Junzo Kamei, Shunsuke Hayashi, Akane Sakai, Yuki Nakanishi, Misa Kai, Megumi Ikegami, Hiroko Ikeda   +6 more
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Chemopreventive effects of Xiang Sha Liu Jun Zi Tang on paclitaxel-induced leucopenia and neuropathy in animals

Frontiers in Pharmacology, 2023
Paclitaxel frequently induces peripheral neuropathy and myelosuppression during cancer treatment. According to the National Health Insurance Research Database of Taiwan, traditional Chinese medicine doctors widely use Xiang Sha Liu Jun Zi Tang (XSLJZT ...
Her-Shyong Shiah, Her-Shyong Shiah, Her-Shyong Shiah, Chia-Jung Lee, Chia-Jung Lee, Chia-Jung Lee, Fang-Yu Lee, Sung-Hui Tseng, Sung-Hui Tseng, Shih-Han Chen, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang, Ching-Chiung Wang   +13 more
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