Results 81 to 90 of about 281,052 (341)

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors. [PDF]

, 2019
Purpose:To evaluate the safety, recommended phase II dose (RP2D) and efficacy of pexidartinib, a colony stimulating factor receptor 1 (CSF-1R) inhibitor, in combination with weekly paclitaxel in patients with advanced solid tumors.
Coussens, Lisa M, Dowlati, Afshin, Karlin, David A, Le, Mai H, Marimuthu, Adhirai, Peck, Alexandra, Reebel, Laura, Rodal, Mary Beth, Rugo, Hope S, Severson, Paul, Sharma, Neelesh, Wesolowski, Robert, West, Brian L   +12 more
core  

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Paclitaxel Increases High Voltage–Dependent Calcium Channel Current in Dorsal Root Ganglion Neurons of the Rat

Journal of Pharmacological Sciences, 2012
Peripheral neuropathic pain is a serious side effect of paclitaxel treatment. However, the mechanism of this paclitaxel-induced neuropathic pain is unknown. In this study, we investigated the effects of paclitaxel on the voltage-dependent calcium channel
Kazuyoshi Kawakami, Terumasa Chiba, Nobuyuki Katagiri, Maya Saduka, Kenji Abe, Iku Utsunomiya, Toshihiro Hama, Kyoji Taguchi   +7 more
doaj  

Joule‐Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures

Advanced Functional Materials, EarlyView.
Joule‐assisted nanotherapeutic urethral stent harnesses a smart, biodegradable magnesium stent to orchestrate spatiotemporal theragenerative therapy for urethral strictures. Magnetically induced Joule heating enables on‐demand drug release and bacterial ablation, while simultaneously guiding urothelial regeneration.
Yuhyun Na, Yubeen Park, Hyun Lee, Song Hee Kim, Seojoon Bang, Hyeong Seok Kang, Chan Ho Moon, Ju Yeong Gwon, Jong Hwa Seo, Min‐Ho Kang, Soo‐Hong Lee, Gi Doo Cha, Wooram Park, Heemin Kang, Jung‐Hoon Park, Hyun‐Do Jung   +15 more
wiley   +1 more source

First line treatment of advanced non-small-cell lung cancer – specific focus on albumin bound paclitaxel

International Journal of Nanomedicine, 2013
Neha Gupta, Hassan Hatoum, Grace K DyDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USAAbstract: Lung cancer is the leading cause of cancer mortality worldwide in both men and women.
Gupta N, Hatoum H, Dy GK
doaj  

Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory

Mediators of Inflammation, 2018
The chemotherapeutic agent paclitaxel is widely used for cancer treatment. Paclitaxel treatment impairs learning and memory function, a side effect that reduces the quality of life of cancer survivors. However, the neural mechanisms underlying paclitaxel-
Zhao Li, Shuang Zhao, Hai-Lin Zhang, Peng Liu, Fei-Fei Liu, Yue-Xian Guo, Xiu-Li Wang   +6 more
doaj   +1 more source

El Paclitaxel

Revista de Química, 2015
Actualmente, el cáncer es una causa importante de mortalidad en el mundo. El paclitaxel es un fármaco que actúa de forma eficiente frente a un gran número de tipos de cáncer y se obtiene, principalmente, a partir de especies de tejo (Taxus spp.), un árbol de la familia de las taxáceas.
Barrales-Cureño, Hebert Jair, Castillo Hernández, Felipe de Jesús, Barros González, Luis Carlos   +2 more
openaire   +2 more sources

Paclitaxel in Breast Cancer

Women's Health, 2006
Paclitaxel, a chemotherapeutic drug isolated from the Pacific yew, was approved for the treatment of metastatic breast cancer in 1994 and remains one of the most important agents in the treatment of patients with this disease. It is currently approved for the adjuvant treatment of node-positive breast cancer, administered sequentially after a standard
Sharon H. Giordano, Debra A. Patt, Michelle Gauthier   +2 more
openaire   +3 more sources

MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. [PDF]

, 2015
Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic.
Amiji, Mansoor M, Choy, Edwin, Duan, Zhenfeng, Hornicek, Francis J, Iyer, Arun K, Singh, Amit, Yang, Xiaoqian   +6 more
core   +1 more source