Results 81 to 90 of about 196,807 (276)

Distinct safety profiles of albumin-bound nab-paclitaxel and paclitaxel in pancreatic cancer focusing on hematologic and hepatobiliary risks

Scientific Reports
Nab-paclitaxel (albumin-bound paclitaxel) and traditional paclitaxel are both used in pancreatic cancer treatment, but their adverse event (AE) profiles may differ due to formulation differences.
Nan Qin, Zhongliu Bian, Jingtao Chen
doaj   +1 more source

In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons

Frontiers in Pharmacology, 2018
Purpose: Drug coated balloons (DCB) are continually improving due to advances in coating techniques and more effective excipients. Paclitaxel, the current drug choice of DCB, is a microtubule-stabilizing chemotherapeutic agent that inhibits smooth muscle
Emily Turner, Megan Erwin, Marzieh Atigh, Uwe Christians, Justin M. Saul, Saami K. Yazdani   +5 more
doaj   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Supplementary Figure Legends from Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL [PDF]

, 2023
Ting‐Yu Chang, Hsin‐An Chen, Ching‐Feng Chiu, Yi‐Wen Chang, Tsang‐Chih Kuo, Po‐Chun Tseng, Weu Wang, Mien‐Chie Hung, Jen-Liang Su   +8 more
openalex   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Cyclosporine A Decreased Paclitaxel Resistance in Prostate Cancer Cells by Inhibiting MTDH Expression

American Journal of Men's Health
This study aims to investigate the effect and mechanism of cyclosporine A (CsA) on paclitaxel-resistant prostate cancer cells. Paclitaxel-resistant prostate cancer cell lines were established by gradual increment method.
Jiangtao Li, Yuzhi Li, Xiaohong Zhang, Kun Liu, Shiping Yang, Zhang Liu, Sheng Cao, Dongfei Ren, Menghui Cui, Jia Su, Zewang Zhen, Donghong Zhang   +11 more
doaj   +1 more source

Dynamic Model of Paclitaxel Biosynthesis Suggests That the Key Enzyme Is Taxadiene 5alpha-Hydroxylase in Taxuschinensis Cell Suspension Culture [PDF]

, 2015
Shifang Zhu, Zhuang Miao
openalex   +1 more source

Phase Ib study of HSP90 inhibitor, onalespib (AT13387), in combination with paclitaxel in patients with advanced triple-negative breast cancer

, 2023
Nicole Williams, Dionisia Quiroga, Courtney Johnson, Adam Brufsky, Mara Chambers, Saveri Bhattacharya, Maria Patterson, Sagar Sardesai, Daniel G. Stover, Maryam B. Lustberg, Anne M. Noonan, Mathew Cherian, Darlene M. Bystry, Kasey Hill, Min Chen, Mitch A. Phelps, Michael R. Grever, Julie Stephens, Bhuvaneswari Ramaswamy, William E. Carson, Robert Wesolowski   +20 more
openalex   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy [PDF]

, 2014
Ran Namgung, Yeong Mi Lee, Jihoon Kim, Yuna Jang, Byung Heon Lee, In San Kim, Pandian Sokkar, Young Min Rhee, Allan S. Hoffman, Won Jong Kim   +9 more
openalex   +1 more source