Results 101 to 110 of about 213,637 (257)

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC).
Kenichiro Araki, Norio Kubo, Yuhei Miyasaka, Hayato Ikota, Ryo Muranushi, Mariko Tsukagoshi, Takamichi Igarashi, Masahiko Okamoto, Tatsuya Ohno, Ken Shirabe   +9 more
wiley   +1 more source

Metabolism of 7-epi-paclitaxel by Human Cytochrome P450 Enzymes: Effect of Epimer-epimer Interaction on the Metabolic Elimination of Paclitaxel

, 2008
-epi-paclitaxel is the principal degradant of paclitaxel under physiological conditions. Human liver microsomal incubation of 7-epi-paclitaxel in the presence of NADPH resulted in the formation of two monohydroxylated metabolites (M-1 and M-2), which ...
张延延, 张江伟, 葛广波, 刘勇, 杨凌   +4 more
core  

Table_2_nab-Paclitaxel-Based Therapy in Underserved Patient Populations: The ABOUND.70+ Study in Elderly Patients With Advanced NSCLC.docx

, 2018
The phase 4 ABOUND.70+ trial assessed the safety and efficacy of nab-paclitaxel/carboplatin continuously or with a 1-week break between cycles in elderly patients with advanced non-small cell lung cancer (NSCLC).
Matei P. Socoteanu (5546894), Teng J. Ong (5546897), Manuel Modiano (5546885), Kartik Konduri (5546879), Eric C. Anderson (3073926), Jonathan W. Goldman (5546906), on behalf of the ABOUND.70+ Investigators (5546903), Daniel E. Haggstrom (5546888), Edward S. Kim (2183847), Corey J. Langer (5546882), Robert M. Jotte (5546891), Tymara Berry (5546843), Jared Weiss (5546900), Christopher Dakhil (5546876), Alexandra Sanford (5546849), Katayoun Amiri (5546870), David A. Smith (2577271)   +16 more
core   +1 more source

Achievement of the Ideal Outcome After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Is Associated With Earlier Initiation and Higher Completion Rates of Adjuvant Chemotherapy and Improved Long‐Term Survival

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Ideal Outcome is a composite quality indicator reflecting optimal postoperative course after pancreatic surgery. This study aimed to clarify the prognostic significance of achieving the Ideal Outcome and its influence on the initiation and completion of adjuvant chemotherapy.
Ryosuke Fukushima, Kenichiro Araki, Ryo Muranushi, Kouki Hoshino, Kei Hagiwara, Shunsuke Kawai, Mariko Tsukagoshi, Takamichi Igarashi, Norio Kubo, Ken Shirabe   +9 more
wiley   +1 more source

Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans

, 2018
Ying Fei Li,1 Chengyue Zhang,1 Simon Zhou,1 Miao He,2 Huixia Zhang,2 Nianhang Chen,1 Feng Li,2 Xin Luan,2 Manjunath Pai,3 Hebao Yuan,2 Duxin Sun,2 Yan Li1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ 07901, USA ...
Luan X, Chen N, Pai M, Li Y, Zhou S, Zhang H, Li F, He M, Sun D, Zhang C, Yuan H, Li YF   +11 more
core  

Presentation_1_nab-Paclitaxel-Based Therapy in Underserved Patient Populations: The ABOUND.70+ Study in Elderly Patients With Advanced NSCLC.PDF

, 2018
The phase 4 ABOUND.70+ trial assessed the safety and efficacy of nab-paclitaxel/carboplatin continuously or with a 1-week break between cycles in elderly patients with advanced non-small cell lung cancer (NSCLC).
Matei P. Socoteanu (5546894), Teng J. Ong (5546897), Manuel Modiano (5546885), Kartik Konduri (5546879), Eric C. Anderson (3073926), Jonathan W. Goldman (5546906), on behalf of the ABOUND.70+ Investigators (5546903), Daniel E. Haggstrom (5546888), Edward S. Kim (2183847), Corey J. Langer (5546882), Robert M. Jotte (5546891), Tymara Berry (5546843), Jared Weiss (5546900), Christopher Dakhil (5546876), Alexandra Sanford (5546849), Katayoun Amiri (5546870), David A. Smith (2577271)   +16 more
core   +1 more source

Cyclosporine A Decreased Paclitaxel Resistance in Prostate Cancer Cells by Inhibiting MTDH Expression

American Journal of Men's Health
This study aims to investigate the effect and mechanism of cyclosporine A (CsA) on paclitaxel-resistant prostate cancer cells. Paclitaxel-resistant prostate cancer cell lines were established by gradual increment method.
Jiangtao Li, Yuzhi Li, Xiaohong Zhang, Kun Liu, Shiping Yang, Zhang Liu, Sheng Cao, Dongfei Ren, Menghui Cui, Jia Su, Zewang Zhen, Donghong Zhang   +11 more
doaj   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel

, 2009
The C-7 chiral centre in paclitaxel is subject to epimerization under physiological conditions, thus making 7-epi-paclitaxel as the principal degradant.
Wang, L. -M., 杨凌, Liu, Y., Ge, G. -B., Sun, J., Zhang, Y. -Y., Zhang, J. -W., Yang, L.   +7 more
core   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source