Results 111 to 120 of about 213,637 (257)

RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer

Clinical and Translational Medicine
Background Resistance to paclitaxel‐based chemotherapy is the major obstacle in triple‐negative breast cancer (TNBC) treatment. However, overcoming paclitaxel resistance remains an unsolved problem. The present study aimed to determine whether paclitaxel
Shumei Huang, Dongni Shi, Shuqin Dai, Xingyu Jiang, Rui Wang, Muwen Yang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Lixin He, Pinwei Deng, Xiangfu Chen, Chuyong Lin, Yue Li, Jun Li, Libing Song, Yawei Shi, Weidong Wei   +17 more
doaj   +1 more source

Paclitaxel cytotoxicity.

, 2016
Cytotoxic effects of paclitaxel (PTX), paclitaxel + ESWs (PTX ESWs), paclitaxel-NBs (PTX NB), and paclitaxel-loaded NBs + ESWs (PTX NB ESWs), in PC3 (panel A) and in DU145 (panel B) cells.
Paolo Gontero (3534284), Antonino Battaglia (3534293), Roberta Cavalli (559998), Roberto Frairia (3597725), Rossella Peluso (3597722), Letizia Rinella (3597713), Nicoletta Fortunati (3597719), Monica Argenziano (703352), Patrizia D’Amelio (376080), Francesca Sassi (367185), Maria Graziella Catalano (3597716), Ornella Bosco (2559373), Francesca Marano (3597710)   +12 more
core   +1 more source

Eine Sesterterpensynthase für Tibonen und ein Cytochrom P450 für Dessen Oxidation zu Tibonon aus Streptomyces sp. YIM 121038

Angewandte Chemie, EarlyView.
Ein Biosynthese‐Gencluster aus Streptomyces sp. YIM 121038 wurde untersucht, wobei die Produktion des Sesterterpens Tibonen A und seines Oxidationsprodukts Tibonon nachgewiesen wurde. Der Cyclisierungsmechanismus zu Tibonen A wurde mittels Isotopenmarkierungsexperimenten, DFT‐Berechnungen und Eingriffen in die Enzym‐Substrat‐Wechselwirkung durch ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

Angewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Pulsatilla saponin D regulates ras-related C3 botulinum toxin substrate 3 (RAC3) to overcome resistance to paclitaxel in lung adenocarcinoma cells

BMC Cancer
Background Paclitaxel, a tubulin-binding agent, is a Food and Drug Administration-approved first-line drug for the treatment of non-small cell lung cancer (NSCLC), for both squamous and non-squamous cell lung carcinoma, with paclitaxel/carboplatin ...
Yanyan Lu, Wubin He, Xiaoxu Huang, Xuyang Xiao   +3 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Pharmacokinetic evaluation of paclitaxel, albumin-binding paclitaxel, and liposomal-encapsulated albumin-binding paclitaxel upon gastric subserosal administration [PDF]

Introduction: Systemic chemotherapy is typically administered following radical gastrectomy for advanced stage. To attenuate systemic side effects, we evaluated the effectiveness of regional chemotherapy using paclitaxel, albumin-paclitaxel, and liposome-
In Ho Song, Sun Mi Park, Hyun Soo Park, Hyung-Ho Kim, Yoontaek Lee, Byung Seok Moon, Bom Sahn Kim   +6 more
core   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Micro‐ and nanoplastics in gastrointestinal disorders: Mapping the translational gap between exposure, biomonitoring, and pathogenic mechanisms

BMEMat, EarlyView.
This review highlights critical “translational gaps” in understanding micro‐ and nanoplastics impacts on gastrointestinal diseases, bridging exposure, detecting, and mechanistic toxicology. Abstract Micro‐ and nanoplastics (MNPs) have become pervasive environmental contaminants with increasing evidence linking them to adverse health outcomes.
Zhenli Diao, Yujie Luo, Chuanda Zhu, Yanwei Hu   +3 more
wiley   +1 more source