Results 81 to 90 of about 213,637 (257)

Correction to “Effect of Paclitaxel Stereochemistry on X‑ray-Triggered Release of Paclitaxel from CaWO₄/Paclitaxel-Coloaded PEG-PLA Nanoparticles”

, 2023
Correction to “Effect of Paclitaxel Stereochemistry on X‑ray-Triggered Release of Paclitaxel from CaWO4/Paclitaxel-Coloaded PEG-PLA ...
Sandra E. Torregrossa-Allen, Mark P. Langer (13047863), You-Yeon Won, Kaustabh Sarkar, Sanjeev Narayanan (744824), Kaustabh Sarkar (10756018), Gregory A. Durm, Bennett D. Elzey, Gregory A. Durm (10661276), You-Yeon Won (1286847), Sanjeev Narayanan, Bennett D. Elzey (3341810), Mark P. Langer, Sandra E. Torregrossa-Allen (13047860)   +13 more
core   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer

PLoS ONE, 2021
Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses for most patients, chemotherapy resistance frequently leads to recurrent or refractory ...
J. Robert McCorkle, Justin W. Gorski, Jinpeng Liu, McKayla B. Riggs, Anthony B. McDowell, Nan Lin, Chi Wang, Frederick R. Ueland, Jill M. Kolesar   +8 more
doaj  

Efficacy and safety of nanoparticle albumin-bound paclitaxel in non-small cell lung cancer: a systematic review and meta-analysis

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Nanoparticle albumin-bound paclitaxel (Nab-paclitaxel) offer more efficient paclitaxel delivery into tumor cells with fewer side effects than conventional chemotherapies.
Hong Tan, Jing Hu, Shan Liu
doaj   +1 more source

Nab-paclitaxel, docetaxel, or solvent-based paclitaxel in metastatic breast cancer: a cost-utility analysis from a Chinese health care perspective

, 2015
George Dranitsaris,1 Bo Yu,2 Jennifer King,3 Satyin Kaura,3 Adams Zhang3 1Augmentium Pharma Consulting Inc., Toronto, ON, Canada; 2Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China; 3Celgene Corporation, Summit, NJ, USA ...
Yu B, King J, Dranitsaris G, Kaura S, Zhang A   +4 more
core  

CTGF increases drug resistance to paclitaxel by upregulating survivin expression in human osteosarcoma cells

, 2014
[[abstract]]Osteosarcoma is the most common primary malignant tumor, and its treatments require more effective therapeutic approaches. Paclitaxel has a broad range of antitumor activities, including apoptosis-inducing effects.
Ts, Hsiao-Chi;Tsai, Hsiao-Chi;Hua, Chun-Yin;Huang, Chun-Yin;Su, Hong-Lin;Su, Hong-Lin;湯智昕;Chih-Hsin, Tang, Ts, Hsiao-Chi;Tsai, Hsiao-Chi;Hua, Chun-Yin;Huang, Chun-Yin;Su, Hong-Lin;Su, Hong-Lin;湯智昕;Chih-Hsin, Tang *   +1 more
core   +1 more source

Safety and Efficacy of nab-Paclitaxel in the Treatment of Patients with Breast Cancer

, 2011
Taxanes are highly active chemotherapeutic agents in the treatment of early-stage and metastatic breast cancer. Novel formulations have been developed to improve efficacy and decrease toxicity associated with these cytotoxic agents.
Vivek Roy, Prakash Vishnu
core   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Angewandte Chemie, EarlyView.
Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan, Shang Zhu, Hang Song, Fei Wang, Zikai He, Sijie Chen, Engui Zhao   +6 more
wiley   +2 more sources

Rationalization of paclitaxel insensitivity of yeast β-tubulin and human βIII-tubulin isotype using principal component analysis

BMC Research Notes, 2012
Background The chemotherapeutic agent paclitaxel arrests cell division by binding to the hetero-dimeric protein tubulin. Subtle differences in tubulin sequences, across eukaryotes and among β-tubulin isotypes, can have profound impact on paclitaxel ...
Das Lalita, Bhattacharya Bhabatarak, Basu Gautam   +2 more
doaj   +1 more source