Results 31 to 40 of about 1,457 (285)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

ETSI EN 319 142 Part 2 (Draft):"" v0.0.3Electronic Signatures and Infrastructures (ESI); PDF Advanced Electronic Signature Profiles; Part 2: PAdES Basic - Profile based on ISO 32000-1 [PDF]

, 2013
Segunda parte del borrador del nuevo estándar europeo que especifica el formato de firmas electrónicas avanzadas para documentos PDF (PAdES). Este documento define un perfil básico de firmas electrónicas avanzadas para las firmas PDF, como se especifican
Rizzo, Luigi, Caccia, Andrea, Röck, Andrea, Cruellas Ibarz, Juan Carlos, Funk, Alexander   +4 more
core   +2 more sources

Village fund management strategies for optimizing village original income to support community empowerment in Sambirejo Village, Indonesia

Journal of Community Service and Empowerment
This study examined how Village Funds (Dana Desa) were managed in Sambirejo Village, Prambanan, Sleman, to optimize Village Original Income (PADes) and strengthen community empowerment.
Abdah Rahmawati, Iis Prasetyo
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

ETSI EN 319 142 Part 5 (Draft): "Electronic Signatures and Infrastructures (ESI); PDF Advanced Electronic Signature Profiles; Part 5: PAdES for XML Content - Profiles for XAdES signatures" v0.0.3 [PDF]

, 2013
Quinta parte del borrador del nuevo estándar europeo que especifica el formato de firmas electrónicas avanzadas para documentos PDF (PAdES). Esta parte define perfiles para una firma XAdES que firma un documento XML que a su vez se introduce dentro de un
Rizzo, Luigi, Röck, Andrea, Cruellas Ibarz, Juan Carlos, Funk, Alexander   +3 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Kaip ugdome mokinių kognityvinius gebėjimus

Lietuvos Matematikos Rinkinys, 2018
Straipsnyje pristatoma revizuota Bloom-o taksonomija ir jos taikymo patirtys išsivysčiusiose pasaulio šalyse. Taip pat gvildenama kognityvinių gebėjimų ugdymo Lietuvoje situacija. Išryškinama Bloom-o taksonomijos taikymo visose švietimo sistemos grandyse
Viktorija Sičiūnienė
doaj   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

FEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li, Miao Xin, Xiao‐wen Cui, Shi‐yin Yu, Fei Meng, Min Cao, Xiao‐hui Xiong, Yi‐chen Lu   +7 more
wiley   +1 more source