Results 91 to 100 of about 371,290 (294)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

What does it mean to experience paediatric depression?: the ethics of mental health diagnosis and treatment in children and adolescents [PDF]

, 2012
This thesis explores the ethics of mental health diagnosis and treatment in children and adolescents through a collection of different perspectives based on literature analysis and interviews with practising clinicians.
Deacutis, Molly
core   +2 more sources

Modifying a paediatric rational prescribing tool (POPI) for use in the UK [PDF]

, 2019
Rational prescribing tools can be used by individual prescribers, organisations, and researchers to evaluate the quality of prescribing for research and quality improvement purposes.
Imti Choonara, Corrick, Fenella, Choonara, Imti, Fenella Corrick, Sammons, Helen, Conroy, Sharon, Sharon Conroy, Helen Sammons   +7 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Paediatric Neurology and Paediatric Neurologists [PDF]

Developmental Medicine & Child Neurology, 1994
M, Bax, K, Brown
openaire   +2 more sources

Airway devices in paediatric anaesthesia

Indian Journal of Anaesthesia, 2019
Airway devices were first used in children since 1940 and thereafter an increasingly large number of paediatric airway devices have come into our armamentarium.
Sarbari Swaika, Sujata Ghosh, Chiranjib Bhattacharyya   +2 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Managing the pediatric patient with refractory asthma: a multidisciplinary approach

Journal of Asthma and Allergy, 2017
James Cook,1,2 Fran Beresford,2 Valentina Fainardi,1 Pippa Hall,2 Georgie Housley,2 Angela Jamalzadeh,2 Michelle Nightingale,2 David Winch,2 Andrew Bush,1,2 Louise Fleming,1,2 Sejal Saglani1,2 1Inflammation, Repair and Development, National Heart and ...
Cook J, Beresford F, Fainardi V, Hall P, Housley G, Jamalzadeh A, Nightingale M, Winch D, Bush A, Fleming L, Saglani S   +10 more
doaj  

European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe.

, 2008
The ESPGHAN-ESPID Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe are the outcome of an important task that the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) has ...
Gendrel D, European Society for Paediatric Infectious D.i.s.e.a.s.e.s., Ashkenazi S, Szajewska H, European Society for Paediatric Gastroenterology, Hepatology, Albano F, Nutrition, Hoekstra JH, GUARINO, ALFREDO, Shamir R   +9 more
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source