Results 61 to 70 of about 534,329 (316)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Clinical Characteristics and Follow-Up of Children with Primary Haematogenous Osteomyelitis and Septic Arthritis: Eight Years of Experience from Hungary

Antibiotics
Introduction: Paediatric acute haematogenous bone and joint infections (BJIs) are serious conditions. This study aimed to analyse the characteristics of paediatric acute haematogenous osteomyelitis (AHO) and septic arthritis (SA) in Hungary, with a focus
Szofia Hajósi-Kalcakosz, Erzsébet Varga, Dorottya Őri, Csaba Ráskai, Borbála Zsigmond, Beáta Visy, Ferenc Fekete, Andrea Horváth, Orsolya Dobay, Bálint Gergely Szabó   +9 more
doaj   +1 more source

Liver Abscess Complicated with an Inflammatory Myofibroblastic Tumor

Journal of the Belgian Society of Radiology, 2022
Inflammatory myofibroblastic tumors have a wide spectrum of biological behaviour and are composed of inflammatory cells and myofibroblastic spindle cells. Tumors may infrequently involve the liver. Imaging findings are non-specific.
Susana Rodrigues, Fábio Ferreira, Sílvia Dias   +2 more
doaj   +1 more source

A comparison of clinical paediatric murmur assessment with echocardiography [PDF]

, 2004
Objective: To compare the clinical acumen of paediatric cardiovascular examination between various hospital paediatrician grades. Design: Prospective data collection of clinical and echocardiography findings on paediatric echocardiography referrals ...
Bailey, Mark, Grech, Victor E., Mercieca, Victor, Spiteri, Amaris, Torpiano, John G.   +4 more
core  

Lumen-Apposing Metal Stents for Endoscopic Transgastric Drainage of Pancreatic Fluid Collections in Children—A Case Report and Review of Safety and Efficacy

Children
Background/Objectives: Pancreatic fluid collections (PFCs) in acute pancreatitis require drainage when symptomatic or infected. Walled-off necrosis (WON) is difficult to drain with plastic stents alone.
Irene Wen Hui Tu, Zong Jie Koh, Khek Yu Ho, Sivaramakrishnan Venkatesh Karthik, Vidyadhar Padmakar Mali   +4 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

A randomised trial of early palliative care for maternal stress in infants prenatally diagnosed with single-ventricle heart disease [PDF]

, 2018
Children with single-ventricle disease experience high mortality and complex care. In other life-limiting childhood illnesses, paediatric palliative care may mitigate maternal stress.
Aiyagari, Ranjit, Bhat, Priya, Donohue, Janet, Fifer, Carly, Hancock, Hayley S, Lowery, Ray, Pituch, Ken, Silveira, Maria, Uzark, Karen, Welch, Suzanne, Yu, Sunkyung   +10 more
core   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Creation and validation of a treatment algorithm for skeletally immature patients with acute anterior cruciate ligament injury based on MRI and patient characteristics

Journal of Experimental Orthopaedics
Purpose This study aimed to develop and validate a clinical decision‐making algorithm, the ‘Best ACL‐treatment Based on the Years of the Knee’ (BABY‐Knee) Algorithm, for treating acute anterior cruciate ligament (ACL) injuries in skeletally immature ...
Alberto Grassi, Kyle Borque, Martijn Dietvorst, Emanuele Altovino, Claudio Rossi, Luca Ambrosini, Alice Bondi, Stefano Zaffagnini   +7 more
doaj   +1 more source

Influence of Food on Paediatric Gastrointestinal Drug Absorption Following Oral Administration: A Review

Children, 2015
The objective of this paper was to review existing information regarding food effects on drug absorption within paediatric populations. Mechanisms that underpin food–drug interactions were examined to consider potential differences between adult and ...
Hannah K. Batchelor
doaj   +1 more source