Results 211 to 220 of about 117,142 (268)
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique subfamily of phospholipases A(2), specific for short acyl chains in the sn-2 position of the phospholipid. Their primary substrate is the platelet-activating factor, PAF, from which they cleave an acetyl moiety with concomitant release of lysoPAF.
Z S, Derewenda, Y S, Ho
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Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique subfamily of phospholipases A(2), specific for short acyl chains in the sn-2 position of the phospholipid. Their primary substrate is the platelet-activating factor, PAF, from which they cleave an acetyl moiety with concomitant release of lysoPAF.
Z S, Derewenda, Y S, Ho
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PAF and PAF acetylhydrolase in the nervous system
Journal of Lipid Mediators and Cell Signalling, 1996PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of alpha-, beta- and gamma-subunits. The beta- and gamma-subunits act as a catalytic unit and their amino acid sequences are homologous.
M, Hattori, J, Aoki, H, Arai, K, Inoue
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PAF Receptor And “Cache-Oreilles” Effect. Simple PAF Antagonists
Lipids, 1991AbstractNine simple and structurally flexible PAF antagonists were synthesized and their inhibitory effects on PAF induced platelet aggregation were measured. Compounds with PAF antagonistic activity exhibited a negative electrostatic potential generated by two trimethoxyphenyl groups (isocontour at −10 Kcal/mole) at various distances between the ...
J, Lamotte-Brasseur +8 more
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Pulmonary vascular reactivity: effect of PAF and PAF antagonists
Journal of Applied Physiology, 1992We investigated the effects of two different platelet-activating factor (PAF) antagonists, SRI 63–441 and WEB 2086, on PAF-, angiotensin II-, and hypoxia-induced vasoconstrictions in isolated rat lungs perfused with a physiological salt solution. Bolus injection of PAF (0.5 micrograms) increased pulmonary arterial and microvascular pressures and ...
C R, Chen, N F, Voelkel, S W, Chang
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Lipids, 1991
AbstractDifferent hypotheses of the structure of platelet‐activating factor (PAF) receptor based on structure‐activity relationships of agonists and antagonists are reviewed. For an agonistic effect, strong hydrophobic interactions and an ether function are required in position‐1 of the glycerol backbone; chain length limitations and steric hindrance ...
J J, Godfroid +4 more
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AbstractDifferent hypotheses of the structure of platelet‐activating factor (PAF) receptor based on structure‐activity relationships of agonists and antagonists are reviewed. For an agonistic effect, strong hydrophobic interactions and an ether function are required in position‐1 of the glycerol backbone; chain length limitations and steric hindrance ...
J J, Godfroid +4 more
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Platelet activating factor (PAF) and lyso-PAF in psoriasis
Archives of Dermatological Research, 1994Previous studies have shown that scale from lesional psoriatic skin contains substantial amounts of platelet activating factor (PAF). In this study, PAF and its immediate precursor, lyso-PAF, were measured in exudates from abrasions on lesional and uninvolved psoriatic skin, and from skin of healthy subjects.
M R, Judge +5 more
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Porous Aromatic Frameworks (PAFs)
Chemical Reviews, 2020Porous aromatic frameworks (PAFs) represent an important category of porous solids. PAFs possess rigid frameworks and exceptionally high surface areas, and, uniquely, they are constructed from carbon-carbon-bond-linked aromatic-based building units. Various functionalities can either originate from the intrinsic chemistry of their building units or are
Yuyang Tian, Guangshan Zhu
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PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency
Biochemical and Biophysical Research Communications, 2004Approximately 4% of the Japanese population genetically lack plasma platelet activating factor acetylhydrolase (PAF-AH) and show a higher prevalence of thromboembolic disease, but whether they are susceptible to another PAF-related disease, asthma, remains controversial.
Katsuhiko, Naoki +11 more
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