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Pulmonary vascular reactivity: effect of PAF and PAF antagonists

Journal of Applied Physiology, 1992
We investigated the effects of two different platelet-activating factor (PAF) antagonists, SRI 63–441 and WEB 2086, on PAF-, angiotensin II-, and hypoxia-induced vasoconstrictions in isolated rat lungs perfused with a physiological salt solution. Bolus injection of PAF (0.5 micrograms) increased pulmonary arterial and microvascular pressures and ...
C R, Chen, N F, Voelkel, S W, Chang
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PAF-acetylhydrolases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique subfamily of phospholipases A(2), specific for short acyl chains in the sn-2 position of the phospholipid. Their primary substrate is the platelet-activating factor, PAF, from which they cleave an acetyl moiety with concomitant release of lysoPAF.
Z S, Derewenda, Y S, Ho
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Synthesis of a PAF Immunogen and Production of PAF-Specific Antibodies

Lipids, 1991
AbstractPlatelet activating factor (PAF), a naturally occurring phospholipid with many potent physiological and pharmacological activities, is implicated as a mediator of many diseases. An immunoassay for PAF would greatly improve quantitation, and hence PAF‐specific antibodies were required.
M A, Smal, B A, Baldo, J W, Redmond
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Platelet activating factor (PAF) and lyso-PAF in psoriasis

Archives of Dermatological Research, 1994
Previous studies have shown that scale from lesional psoriatic skin contains substantial amounts of platelet activating factor (PAF). In this study, PAF and its immediate precursor, lyso-PAF, were measured in exudates from abrasions on lesional and uninvolved psoriatic skin, and from skin of healthy subjects.
M R, Judge, R M, Barr, A I, Mallet, F, Courtney, A, Kobza Black, M W, Greaves   +5 more
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PAF Receptor And “Cache-Oreilles” Effect. Simple PAF Antagonists

Lipids, 1991
AbstractNine simple and structurally flexible PAF antagonists were synthesized and their inhibitory effects on PAF induced platelet aggregation were measured. Compounds with PAF antagonistic activity exhibited a negative electrostatic potential generated by two trimethoxyphenyl groups (isocontour at −10 Kcal/mole) at various distances between the ...
J, Lamotte-Brasseur, F, Heymans, G, Dive, A, Lamouri, J P, Batt, C, Redeuilh, D, Hosford, P, Braquet, J J, Godfroid   +8 more
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PAF Receptor Structure

Lipids, 1991
AbstractDifferent hypotheses of the structure of platelet‐activating factor (PAF) receptor based on structure‐activity relationships of agonists and antagonists are reviewed. For an agonistic effect, strong hydrophobic interactions and an ether function are required in position‐1 of the glycerol backbone; chain length limitations and steric hindrance ...
J J, Godfroid, G, Dive, J, Lamotte-Brasseur, J P, Batt, F, Heymans   +4 more
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PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency

Biochemical and Biophysical Research Communications, 2004
Approximately 4% of the Japanese population genetically lack plasma platelet activating factor acetylhydrolase (PAF-AH) and show a higher prevalence of thromboembolic disease, but whether they are susceptible to another PAF-related disease, asthma, remains controversial.
Katsuhiko, Naoki, Koichiro, Asano, Nagato, Satoh, Kouichi, Fukunaga, Tsuyoshi, Oguma, Tetsuya, Shiomi, Yusuke, Suzuki, Takeshi, Nakajima, Kyoko, Niimi, Yoshiki, Shiraishi, Akitoshi, Ishizaka, Kazuhiro, Yamaguchi   +11 more
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Paf‐acether in human skin

Lipids, 1991
AbstractPaf is a phospholipid mediator present in human skin which induces inflammatory events such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions.
Y, Denizot, L, Michel, J, Benveniste, A, Meybeck, Y, Thomas, L, Dubertret   +5 more
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Hypoxia, PAF, and Necrotizing Enterocolitis

Lipids, 1991
AbstractNecrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet‐activating factor (PAF) on intestinal blood flow and intestinal necrosis,
M S, Caplan, X M, Sun, W, Hsueh
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Effects of a Novel PAF Antagonist, E6123, on PAF-Induced Biological Responses

European Journal of Pharmacology, 1990
E6123 is a new member of the benzodiazepine class of PAF antagonists. Although it has similar activity in vitro to the two representative antagonists WEB2347 and Y24180, in vivo it is far more active than these compounds. Thus E6123 was effective in inhibiting dose-dependently PAF-induced bronchoconstriction when administered orally or intravenously ...
H. Tsunoda, Y. Sakuma, K. Harada, K. Muramoto, S. Katayama, T. Horie, N. Shimomura, R. Clark, S. Miyazawa, K. Okano, Y. Machida, K. Katayama, I. Yamastu   +12 more
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