Results 291 to 300 of about 146,504 (339)
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Lipids, 1991
AbstractDifferent hypotheses of the structure of platelet‐activating factor (PAF) receptor based on structure‐activity relationships of agonists and antagonists are reviewed. For an agonistic effect, strong hydrophobic interactions and an ether function are required in position‐1 of the glycerol backbone; chain length limitations and steric hindrance ...
J J, Godfroid +4 more
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AbstractDifferent hypotheses of the structure of platelet‐activating factor (PAF) receptor based on structure‐activity relationships of agonists and antagonists are reviewed. For an agonistic effect, strong hydrophobic interactions and an ether function are required in position‐1 of the glycerol backbone; chain length limitations and steric hindrance ...
J J, Godfroid +4 more
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Platelet activating factor (PAF) and lyso-PAF in psoriasis
Archives of Dermatological Research, 1994Previous studies have shown that scale from lesional psoriatic skin contains substantial amounts of platelet activating factor (PAF). In this study, PAF and its immediate precursor, lyso-PAF, were measured in exudates from abrasions on lesional and uninvolved psoriatic skin, and from skin of healthy subjects.
M R, Judge +5 more
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Porous Aromatic Frameworks (PAFs)
Chemical Reviews, 2020Porous aromatic frameworks (PAFs) represent an important category of porous solids. PAFs possess rigid frameworks and exceptionally high surface areas, and, uniquely, they are constructed from carbon-carbon-bond-linked aromatic-based building units. Various functionalities can either originate from the intrinsic chemistry of their building units or are
Yuyang Tian, Guangshan Zhu
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PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency
Biochemical and Biophysical Research Communications, 2004Approximately 4% of the Japanese population genetically lack plasma platelet activating factor acetylhydrolase (PAF-AH) and show a higher prevalence of thromboembolic disease, but whether they are susceptible to another PAF-related disease, asthma, remains controversial.
Katsuhiko, Naoki +11 more
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Hypoxia, PAF, and Necrotizing Enterocolitis
Lipids, 1991AbstractNecrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet‐activating factor (PAF) on intestinal blood flow and intestinal necrosis,
M S, Caplan, X M, Sun, W, Hsueh
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Synthesis of a PAF Immunogen and Production of PAF-Specific Antibodies
Lipids, 1991AbstractPlatelet activating factor (PAF), a naturally occurring phospholipid with many potent physiological and pharmacological activities, is implicated as a mediator of many diseases. An immunoassay for PAF would greatly improve quantitation, and hence PAF‐specific antibodies were required.
M A, Smal, B A, Baldo, J W, Redmond
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Lipids, 1991
AbstractPaf is a phospholipid mediator present in human skin which induces inflammatory events such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions.
Y, Denizot +5 more
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AbstractPaf is a phospholipid mediator present in human skin which induces inflammatory events such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions.
Y, Denizot +5 more
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Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
Nature Structural & Molecular Biology, 2020S. Vos +4 more
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PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover
European Journal of Pharmacology: Molecular Pharmacology, 1995The effect of a new PAF (platelet activating factor; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoryl-choline) receptor antagonist, PCA-4248 (2-phenylthio)ethyl-5-metoxycarbonyl-2,4,6-trimethyl-1, 4-dihydropyridine-3-carboxylate), on phosphoinositide turnover evoked by PAF was investigated.
R E, Catalán +4 more
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