Results 41 to 50 of about 85,073 (223)
Advanced Science, EarlyView.Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen +4 more
wiley +1 more source
Recent Advancements Surrounding the Role of the Periaqueductal Gray in Predators and Prey
Frontiers in Behavioral Neuroscience, 2019 Recent advances in neural circuitry techniques, like optogenetics and chemogenetics, have allowed for a greater understanding of the periaqueductal gray (PAG) and its importance in predator and prey behaviors.
Tamara B. Franklin
doaj +1 more source
Frontiers in Neurology, 2021 Objective: Patients with temporal lobe epilepsy (TLE) are at high risk for having a comorbid condition of migraine, and these two common diseases are proposed to have some shared pathophysiological mechanisms.
Long Wang +6 more
doaj +1 more source
Advanced Science, EarlyView.RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan +8 more
wiley +1 more source
An Update on the Molecular Basis of Phosphoantigen Recognition by Vγ9Vδ2 T Cells
Cells, 2020 About 1–5% of human blood T cells are Vγ9Vδ2 T cells. Their hallmark is the expression of T cell antigen receptors (TCR) whose γ-chains contain a rearrangement of Vγ9 with JP (TRGV9JP or Vγ2Jγ1.2) and are paired with Vδ2 (TRDV2)-containing δ-chains ...
Thomas Herrmann +2 more
doaj +1 more source
Maternal Hyperglycemia Disrupts Cerebral Cortex Development Through the Foxp1‐Dll1‐Notch Axis
Advanced Science, EarlyView.Maternal hyperglycemia disrupts offspring cortical development through a Foxp1–Dll1–Notch signaling axis. In a PGDM mouse model, intrauterine hyperglycemia decreases cortical thickness and perturbs neuronal layering by downregulating Foxp1, which transcriptionally regulates the Notch ligand Dll1.
Longkai He +12 more
wiley +1 more source
Disrupted functional connectivity of the periaqueductal gray in chronic low back pain
NeuroImage: Clinical, 2014 Chronic low back pain is a common neurological disorder. The periaqueductal gray (PAG) plays a key role in the descending modulation of pain. In this study, we investigated brain resting state PAG functional connectivity (FC) differences between patients
Rongjun Yu +5 more
doaj +1 more source
The Effect of Inner Grooved Tubes on the Heat Transfer Performace of Air-Cooled Heat Exchangers of Co2 Heat Pump System [PDF]
, 2012 In the CO2 heat pump system, Poly alkyl glycol (PAG) oil is commonly used for lubrication of the compressor, while it is reported that the PAG oil has influence on the heat transfer performance due to its immiscibility against CO2 within its working ...
Fujino, Hirokazu +2 more
core
Advanced Science, EarlyView.HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu +12 more
wiley +1 more source