The Periaqueductal Gray (PAG) [PDF]
Neural Plasticity, 2009 This issue covers a broad territory of PAG function: neuropharmacology, functional organization, and PAG plasticity in adaptive behavior, emotion, anxiety, and the less-studied plasticity of the PAG function in females.
T. A. Lovick, Robert Adamec
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The role of the periaqueductal gray in escape behavior [PDF]
Current Opinion in Neurobiology, 2020 Escape behavior is a defensive action deployed by animals in response to imminent threats. In mammalian species, a variety of different brain circuits are known to participate in this crucial survival behavior. One of these circuits is the periaqueductal gray, a midbrain structure that can command a variety of instinctive behaviors.
Lefler, Yaara +2 more
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Periaqueductal gray matter echogenicity as a marker of migraine chronification: a case control study [PDF]
The Journal of Headache and Pain, 2023 Background Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis.
Dolores Vilas +8 more
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Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior [PDF]
Cell ReportsSummary: Reward-seeking behaviors often require not only encoding moment-to-moment reward prediction errors but also sustaining reward expectancy in the face of repeated negative outcomes and ongoing effort costs.
Hyunchan Lee, Okihide Hikosaka
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Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved? [PDF]
Neural Plasticity, 2009 Cannabinoids play an important role in activity-dependent changes in synaptic activity and can interfere in several brain functions, including responses to aversive stimuli.
F. A. Moreira +6 more
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Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity [PDF]
Communications BiologySocial identity differences are crucial for gregarious animals, impacting survival and social development. This is particularly evident in humans, where social stratification, cultural divides, and ethnic differences influence societal dynamics.
Kaizhen Peng +7 more
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The periaqueductal gray and Bayesian integration in placebo analgesia
eLife, 2018 In placebo hypoalgesia research, the strength of treatment expectations and experiences are key components. However, the reliability or precision of expectations had been mostly ignored although being a likely source for interindividual differences.
Arvina Grahl +2 more
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Induction of flight via midbrain projections to the cuneiform nucleus
PLoS ONE, 2023 The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in
Emmy Tsang +7 more
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A Novel Role for the Periaqueductal Gray in Consummatory Behavior
Frontiers in Behavioral Neuroscience, 2018 The periaqueductal gray (PAG) has a well-established role in pain processing, autonomic function and behavioral responses to fear. Anatomical work suggests the PAG may mediate food intake and reward processing as it has extensive reciprocal connections ...
Valerie Lee Tryon +2 more
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Cannabinoids, anxiety, and the periaqueductal gray. [PDF]
Psychology & Neuroscience, 2010 use of Cannabis sativa by humans dates back several thousand years, for both its psychotomimetic and potential medicinal properties. As scientific research methods developed, the cannabinoids present in this herb were characterized, as well as their complex interface with the human central nervous system, provided by the activation of specific ...
Viviane M. Saito, Fabrício A. Moreira
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