Results 21 to 30 of about 478,697 (222)
PLoS ONE, 2014 Several studies have shown that motor cortex stimulation provided pain relief by motor cortex plasticity and activating descending inhibitory pain control systems.
Da-Wei Ye +4 more
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Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice
Nature Communications, 2021 Hunting behavior typically contains a sequential motor program, including search, chase, attack, and consumption. Here, the authors show that periaqueductal gray neuronal ensembles encode the sequential hunting motor program, which might provide a ...
Hong Yu +9 more
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D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats
Molecular Pain, 2016 Background The N-methyl- D -aspartate subtype of glutamate receptor plays a critical role in morphine tolerance. D-serine, a co-agonist of N-methyl- D -aspartate receptor, participates in many physiological and pathophysiological processes via regulating
Song Cao MD, PhD +3 more
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Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain
Molecular Pain, 2019 Background Pain is one of the most common and distressing symptoms suffered by patients with progression of cancer; however, the mechanisms responsible for hyperalgesia are not well understood.
Jian Zhang +4 more
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Chronic Stress, 2019 Background The innate alarm system consists of a subcortical network of interconnected midbrain, lower brainstem, and thalamic nuclei, which together mediate the detection of evolutionarily-relevant stimuli.
Braeden A. Terpou +6 more
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Past, Present, and Future in the Study of Neural Control of the Lower Urinary Tract [PDF]
International Neurourology Journal, 2020 The neurological coordination of the lower urinary tract can be analyzed from the perspective of motor neurons or sensory neurons. First, sensory nerves with receptors in the bladder and urethra transmits stimuli to the cerebral cortex through the ...
Jin Wook Kim, Su Jin Kim, Khae Hawn Kim
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Brazilian Journal of Medical and Biological Research, 2003 The periaqueductal gray (PAG) has been traditionally considered to be an exit relay for defensive responses. Functional mapping of its subdivisions has advanced our knowledge of this structure, but synthesis remains difficult mainly because results from ...
D.M.L. Vianna, M.L. Brandão
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Dorsal periaqueductal gray ensembles represent approach and avoidance states
eLife, 2021 Animals must balance needs to approach threats for risk assessment and to avoid danger. The dorsal periaqueductal gray (dPAG) controls defensive behaviors, but it is unknown how it represents states associated with threat approach and avoidance.
Fernando MCV Reis +12 more
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A Midbrain Circuit that Mediates Headache Aversiveness in Rats
Cell Reports, 2019 Summary: Migraines are a major health burden, but treatment is limited because of inadequate understanding of neural mechanisms underlying headache. Imaging studies of migraine patients demonstrate changes in both pain-modulatory circuits and reward ...
Maggie W. Waung +3 more
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VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source