Results 61 to 70 of about 229 (147)

Mammary Fibroblasts Secrete Damage Associated Molecular Patterns Through Extracellular Vesicles in Response to Ionizing Radiation

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
We show that ionizing radiation (IR)‐induced damage in mammary fibroblasts results in a senescence‐like phenotype including enhanced EV and cytokine secretion. Proteomic profiling revealed that IR‐induced EVs are enriched with damage associated molecular patterns (DAMPs) and pro‐inflammatory mediators.
Greg Berumen Sánchez, Purvi Patel, Preston Gomez‐Crase, Chloe Kim, Kevin C. Corn, Kristie L. Rose, Marjan Rafat   +6 more
wiley   +1 more source

Keratin Expression in Mammary Paget’s Disease in situ with Intraductal Invasion

Case Reports in Oncology, 2012
We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget’s disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD.
Ichiro Kurokawa, Sayaka Furukawa, Masahiro Kishimoto, Ayako Kakuno, Airo Tsubura   +4 more
doaj   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Pigmented mammary Paget's disease. dermoscopic, in vivo confocal microscopic, and himmunohistochemical study of a case [PDF]

, 2007
Background: Pigmented mammary Paget disease represents a rare variant of mammary Paget disease that clinically and dermoscopically simulates a melanoma. We report a case of pigmented mammary Paget disease mimicking a melanoma and describe the dermoscopic,
FANTINI F, CESINARO AM, LONGO C, PELLACANI G, BASSOLI S, S. SEIDENARI   +5 more
core   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Single‐Center Epidemiological Analysis of Malignant Transformation With Skin Ulcers in Outpatients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT Investigate the epidemiological characteristics of outpatients initially diagnosed with skin ulcers who were ultimately confirmed to have cutaneous malignant tumours, and provide a diagnostic and therapeutic basis for the occurrence of secondary diseases in chronic wounds.
Yaoyao Kong, Haixia Wang, Nan Cao, Pengcheng Huai, Zhenzhen Wang, Chaoqi Zuo, Xueqing Wang, Yilei Wu, Yongxia Liu, Shengli Chen, Hong Liu, Guangliang Zhang   +11 more
wiley   +1 more source

Dermoscopy Case of the Month [PDF]

, 2017
Mammary Paget's disease is a rare intraepithelial carcinoma of the nipple/areola complex often associated with ductal breast carcinoma. We report a case of a 55-year-old female patient with a classical form of mammary Paget's disease associated ductal ...
Tatjana Roš, Marijana Badrkić, Marijana Macanović, Branislava Gajić, Nenad Šolajić   +4 more
core   +1 more source

Cutaneous Metastasis: A Retrospective Clinicopathological and Prognostic Analysis of 62 Patients From a Tertiary Center in China

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Cutaneous metastases are uncommon but clinically significant manifestations of internal malignancies and may indicate advanced disease or, in certain cases, represent the initial sign of cancer. Their variable clinical and histopathologic presentations can pose diagnostic challenges, particularly when the primary tumor is unknown.
Qiannan Jia, Xinran Li, Jun Li, Suraiya Saleem   +3 more
wiley   +1 more source

The Roles of MicroRNAs, Oncogenes, and Tumor Suppressor Gene Molecular Subtypes of Breast Cancer: Therapeutic Potential of Pharmaceutical and Natural Products

International Journal of Breast Cancer, Volume 2026, Issue 1, 2026.
Background Breast cancer (BC) is the most common malignancy among women, with 2.3 million new cases and over 670,000 deaths annually. Despite advances in detection and therapy, relapse, metastasis, and resistance remain significant challenges. Tumor suppressor genes (TSGs) regulate abnormal cell division, whereas oncogenes, which arise from proto ...
Md. Sadikuj Jaman, Md. Maniruzzaman, Md. Rokibul Hasan Bhuiyan, Md Shajedul Haque, Irfan Ahmad   +4 more
wiley   +1 more source

Mammary Paget's disease with acantholytic features and without any detectable breast tumor [PDF]

, 1998
Paget's disease is usually associated with an underlying adenocarcinoma of the breast. The initial manifestation is an eczematous or psoriasiform lesion of the nipple, soon extending to the mammary areola and then to the surrounding skin.
CALVIERI, Stefano, U. Bottoni, G. Pranteda, GUELI, Nicolo', PRANTEDA, Guglielmo   +4 more
core