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Pathogenesis of Paget's Disease of Bone
Clinical Reviews in Bone and Mineral Metabolism, 2002Paget's disease of bone is a common condition characterised by increased and disorganised bone turnover which can affect one or several bones throughout the skeleton. These abnormalities disrupt normal bone architecture and lead to various complications such as bone pain osteoarthritis, pathological fracture, bone deformity, deafness, and nerve ...
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Bone Quality in Paget’s Disease of Bone
Current Osteoporosis Reports, 2016Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity.
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Sir James Paget: Paget's Disease of the Nipple, Paget's Disease of Bone
Journal of Perioperative Practice, 2013Sir James Paget was one of the ‘great’ Victorians. Eminent as a surgeon, pathologist and teacher, his nobility of character and application to his work made him a leader in his profession in that age of great men.
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Treatment of Paget's Disease of Bone
Postgraduate Medicine, 1975Patients with Paget's disease of bone often are asymptomatic, but many are severely disabled by skeletal deformity and bone pain. Recently introduced agents show promise in suppressing the increased skeletal metabolic activity and decreasing the bone pain.
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