Results 51 to 60 of about 166,331,801 (189)

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone

, 2006
Paget's disease is a focal condition of bone. To study changes in cells within pagetic lesions, we cultured osteoblasts and stromal cells from 22 patients and compared gene expression in these cells to cells from healthy bone.
Gamble, Gregory, Black, M, Usha Bava, Reid, Ian, Song, S, Pitto, Rocco, Song, Sarah, Cundy, Timothy, Tim Cundy, Bava, Usha, Cundy, Tim, Rocco P Pitto, Matthews, Brya, Ian R Reid, Karen E Callon, Bava, U, Michael Black, Callon, Karen E, Reid, Ian R, Sarah Song, Pitto, Rocco P, Brya Matthews, Naot, Dorit, Black, Michael, Gregory D Gamble, Callon, KE, Gamble, Gamble D, Jill Cornish, Cornish, Jillian, Cornish, Jill, Dorit Naot   +30 more
core   +1 more source

Human dissection and comparative anatomy: Archaeological evidence for nineteenth‐century anatomical practice at University College London

Journal of Anatomy, EarlyView.
Excavation at University College London revealed more than 8700 human skeletal fragments representing at least 38 individuals, alongside over 800 animal remains. Features consistent with dissection, specimen preparation and curation provide evidence for the use of human and animal material in nineteenth‐century anatomical education, offering rare ...
Wendy Birch, Tania Kausmally
wiley   +1 more source

Paget’s disease of the bone (early diagnosis): How far is far away? [PDF]

Romanian Journal of Medical Practice, 2018
Introduction. Paget’s disease of the bone is a skeleton condition affecting bone remodelling of unknown cause. Bone formation and resorption, as parts of bone turnover which are normally coupled in healthy skeleton, in this condition are disconnected. We
Adina Ghemigian, Mara Carsote, Andra Cocolos, Nicoleta Dumitru, Eugenia Petrova, Ana Valea, Raluca Muntean, Andrei Goldstein   +7 more
doaj   +1 more source

Severe Graves' disease‐associated orbitopathy: A rare case of frontal bone hemangioma

Clinical Case Reports, 2021
Graves' orbitopathy might be severe, requiring treatment with high‐dose glucocorticoids. A lytic bone lesion, malignant lesions, and diseases resulting from bone remodeling processes (eg, Paget's disease) must be excluded by markers and imagery. Outcomes
Ahmad Alamri, Daphné Pauchet, André Balaton, Constance Oriez, Olivier Dupuy, Adrien Ben Hamou   +5 more
doaj   +1 more source

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Cells, 2023
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant   +15 more
doaj   +1 more source

Autogenous Demineralized Dentin Graft–Based Strategies With or Without I‐PRF and Metronidazole for Ridge Preservation in Infected Sockets: A Randomized Clinical Trial

Journal of Periodontal Research, EarlyView.
This randomized controlled trial evaluated the efficacy of demineralized dentin graft (DDG) combined with injectable platelet‐rich fibrin (I‐PRF) and metronidazole (MTZ) versus DDG with or without I‐PRF in alveolar ridge preservation (ARP) of infected extraction sockets.
Mohamed Talaat Elbehwashy, Manal Mohamed Hosny, Ahmed Elfana, Heba Ahmed Saleh, Karim Fawzy El‐Sayed   +4 more
wiley   +1 more source

Durability of Response to Zoledronate Treatment and Competing Mortality in Paget's Disease of Bone

, 2017
There has been a marked secular trend in recent decades toward patients with Paget's disease presenting at a greater age and having less extensive skeletal involvement.
Grey, Andrew, Reid, Ian, Maslowski, K, Cundy, Timothy   +3 more
core   +1 more source

Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone [PDF]

, 2018
Paget's disease of bone (PDB) is the second most frequent metabolic bone disease after osteoporosis. Genetic factors play an important role in PDB, but to date PDB causing mutations were identified only in the Sequestosome 1 gene at the PDB3 locus.
Conceição, Natércia, Iris A.L. Silva, Gagnon, Edith, Brown, Jacques P., M. Leonor Cancela, Laëtitia Michou, Silva, Iris, Caiado, Helena, Gianfrancesco, Fernando, Natércia Conceição, Michou, Laëtitia, Jacques P. Brown, Helena Caiado, Fernando Gianfrancesco, Édith Gagnon, Cancela, Leonor   +15 more
core   +1 more source

TREATMENT OF PAGET'S DISEASE OF BONE [PDF]

Clinical Endocrinology, 1988
There are two major types of agent available to suppress disease activity: calcitonin, and the bisphosphonates (formerly called diphosphonates). Other agents, including fluoride, mithramycin, actinomycin-D, glucocorticoids, colchicine, glucagon and inosiplex, have also been investigated, but are either ineffective, toxic or ...
D, Anderson, J C, Cantrill
openaire   +3 more sources