Results 41 to 50 of about 6,622 (149)

Palbociclib in the Treatment of HR+/ HER2‐ Advanced or Metastatic Breast Cancer in Australia: A Real‐World Retrospective Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This study investigated the real‐world use of CDK4/6 inhibitors in Australian patients with HR+/HER2‐ advanced or metastatic breast cancer, providing data on patient demographics, treatment patterns, and outcomes with palbociclib. ABSTRACT Background There is limited real‐world data on the use of CDK4/6 inhibitors in Australian patients with HR+/HER2 ...
Louise Nott, Eugene Moylan, Maree Colosimo, Giles Stratton, Thomas Chiu, Mahsa H. Kouhkamari, Maureen Hitschfeld, Jessica Michie, Richard De Boer   +8 more
wiley   +1 more source

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

Frontiers in Endocrinology, 2021
Paget’s disease of bone (PDB) is a common skeleton disorder in which the diagnosis is suggested by radiological analyses. Congenital generalized lipodystrophy (CGL) is a rare, but a radiologic differential diagnosis of Paget’s disease.
Erika Bastos Lima Freire, Erika Bastos Lima Freire, Erika Bastos Lima Freire, Mayara Ponte Madeira, Mayara Ponte Madeira, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Grayce Ellen da Cruz Paiva Lima, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Virginia Oliveira Fernandes, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, João Paulo Uchoa Fontenele, Ana Paula Dias Rangel Montenegro, Thyciara Fontenele Marques, Renan Galvão Ozório, Catarina Brasil d’Alva, Catarina Brasil d’Alva, Catarina Brasil d’Alva, Renan Magalhães Montenegro, Renan Magalhães Montenegro, Renan Magalhães Montenegro   +22 more
doaj   +1 more source

Alterations of bone proteins in medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 133, Issue 2, April 2025.
Abstract Changes in the protein expression pattern of osteoblastic lineage cells from the alveolar bone (OLAB) during medication‐related osteonecrosis of the jaw (MRONJ) have rarely been investigated. This lack of information is partly because of the limited availability of healthy samples and the lack of human alveolar bone cell lines for research ...
Andrea Schubert, Phillipp Brockmeyer, Philipp Kauffmann, Jan Wiegel, Florian Lautenbacher, Nicolai Miosge, Boris Schminke   +6 more
wiley   +1 more source

Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of bone): A questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventive treatment if they were available

BMC Health Services Research, 2008
Background Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
McCallum Marilyn, Weinman John, MacLennan Graeme, Marteau Theresa, Entwistle Vikki A, Campbell Marion K, Robertson Clare, Francis Jill, Johnston Marie, Langston Anne L, Miedzybrodska Zosia, Charnock Keith, Ralston Stuart H   +12 more
doaj   +1 more source

Paget’s disease of the bone (early diagnosis): How far is far away? [PDF]

Romanian Journal of Medical Practice, 2018
Introduction. Paget’s disease of the bone is a skeleton condition affecting bone remodelling of unknown cause. Bone formation and resorption, as parts of bone turnover which are normally coupled in healthy skeleton, in this condition are disconnected. We
Adina Ghemigian, Mara Carsote, Andra Cocolos, Nicoleta Dumitru, Eugenia Petrova, Ana Valea, Raluca Muntean, Andrei Goldstein   +7 more
doaj   +1 more source

Human dissection and comparative anatomy: Archaeological evidence for nineteenth‐century anatomical practice at University College London

Journal of Anatomy, EarlyView.
Excavation at University College London revealed more than 8700 human skeletal fragments representing at least 38 individuals, alongside over 800 animal remains. Features consistent with dissection, specimen preparation and curation provide evidence for the use of human and animal material in nineteenth‐century anatomical education, offering rare ...
Wendy Birch, Tania Kausmally
wiley   +1 more source

Severe Graves' disease‐associated orbitopathy: A rare case of frontal bone hemangioma

Clinical Case Reports, 2021
Graves' orbitopathy might be severe, requiring treatment with high‐dose glucocorticoids. A lytic bone lesion, malignant lesions, and diseases resulting from bone remodeling processes (eg, Paget's disease) must be excluded by markers and imagery. Outcomes
Ahmad Alamri, Daphné Pauchet, André Balaton, Constance Oriez, Olivier Dupuy, Adrien Ben Hamou   +5 more
doaj   +1 more source

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget’s Disease of Bone

Cells, 2023
Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns, Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman, Jessica L. Bowser, Kathryn Berg, Sachin Wani, Stuart H. Ralston, Matthew J. Hilton, Teresa K. Tarrant   +15 more
doaj   +1 more source

Condylar Trabecular Bone Texture in Temporomandibular Disorders: A Quantitative Computed Tomography Analysis

Journal of Oral Rehabilitation, EarlyView.
Quantitative computed tomography texture analysis revealed differences in mandibular condylar trabecular bone among patients with temporomandibular disorders and asymptomatic controls. Distinct texture features were identified in the peri‐cystic bone of condyles with subchondral cysts, suggesting alterations in local trabecular bone microarchitecture ...
Elaine Dinardi Barioni, Jennifer Larissa Oliveira do Nascimento, Lana Ferreira Santos, Maria Aparecida Neves Jardini, Kaan Orhan, Sérgio Lucio Pereira de Castro Lopes, Andre Luiz Ferreira Costa   +6 more
wiley   +1 more source

TREATMENT OF PAGET'S DISEASE OF BONE [PDF]

Clinical Endocrinology, 1988
There are two major types of agent available to suppress disease activity: calcitonin, and the bisphosphonates (formerly called diphosphonates). Other agents, including fluoride, mithramycin, actinomycin-D, glucocorticoids, colchicine, glucagon and inosiplex, have also been investigated, but are either ineffective, toxic or ...
D, Anderson, J C, Cantrill
openaire   +3 more sources